Beclin-2 (BECN2)

About Beclin-2

Beclin-2 (BECN2) is a protein from Homo sapiens identified by UniProt accession A8MW95, 431 residues long. MolForge cross-references it against 0 known binders and 46 disease associations.

Target properties

Protein name	Beclin-2
UniProt accession	A8MW95
Gene	BECN2
Organism	Homo sapiens
Length	431 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (46)

Diseases linked to this target (Open Targets).

MODY · score 0.07
obesity due to melanocortin 4 receptor deficiency · score 0.06
type 2 diabetes mellitus · score 0.05
hypoinsulinemic hypoglycemia and body hemihypertrophy · score 0.05
transient neonatal diabetes mellitus · score 0.05
severe early-onset obesity-insulin resistance syndrome due to SH2B1 deficiency · score 0.04
metabolite measurement · score 0.04
short stature due to primary acid-labile subunit deficiency · score 0.04
diabetes mellitus, permanent neonatal 4 · score 0.04
diabetes mellitus, transient neonatal, 2 · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A8MW95-F1	alphafold	PREDICTED	75.92	—

Amino-acid sequence (431 residues)

MSSIRFLCQR CHQALKLSGS SESRSLPAAP APTSGQAEPG DTREPGVTTR EVTDAEEQQD GASSRSPPGD GSVSKGHANI FTLLGELGAM HMLSSIQKAA GDIFDIVSGQ AVVDHPLCEE CTDSLLEQLD IQLALTEADS QNYQRCLETG ELATSEDEAA ALRAELRDLE LEEARLVQEL EDVDRNNARA AADLQAAQAE AAELDQQERQ HYRDYSALKR QQLELLDQLG NVENQLQYAR VQRDRLKEIN CFTATFEIWV EGPLGVINNF RLGRLPTVRV GWNEINTAWG QAALLLLTLA NTIGLQFQRY RLIPCGNHSY LKSLTDDRTE LPLFCYGGQD VFLNNKYDRA MVAFLDCMQQ FKEEAEKGEL GLSLPYGIQV ETGLMEDVGG RGECYSIRTH LNTQELWTKA LKFMLINFKW SLIWVASRYQ K

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards