About Endosome/lysosome-associated apoptosis and autophagy regulator family member 2
Endosome/lysosome-associated apoptosis and autophagy regulator family member 2 (ELAPOR2) is a protein
from Homo sapiens identified by UniProt accession
A8MWY0, 1029 residues long.
MolForge cross-references it against 0 known binders and
26 disease associations.
Target properties
| Protein name | Endosome/lysosome-associated apoptosis and autophagy regulator family member 2 |
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| UniProt accession | A8MWY0 |
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| Gene | ELAPOR2 |
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| Organism | Homo sapiens |
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| Length | 1029 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (26)
Diseases linked to this target (Open Targets).
- sex hormone-binding globulin measurement · score 0.26
- schizophrenia · score 0.06
- bipolar disorder · score 0.05
- autism spectrum disorder · score 0.04
- self reported educational attainment · score 0.04
- intelligence · score 0.04
- attention deficit hyperactivity disorder · score 0.03
- unipolar depression · score 0.03
- obsessive-compulsive disorder · score 0.03
- Tourette syndrome · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A8MWY0-F1 | alphafold | PREDICTED | 76.09 | — |
Amino-acid sequence (1029 residues)
MLFRARGPVR GRGWGRPAEA PRRGRSPPWS PAWICCWALA GCQAAWAGDL PSSSSRPLPP CQEKDYHFEY TECDSSGSRW RVAIPNSAVD CSGLPDPVRG KECTFSCASG EYLEMKNQVC SKCGEGTYSL GSGIKFDEWD ELPAGFSNIA TFMDTVVGPS DSRPDGCNNS SWIPRGNYIE SNRDDCTVSL IYAVHLKKSG YVFFEYQYVD NNIFFEFFIQ NDQCQEMDTT TDKWVKLTDN GEWGSHSVML KSGTNILYWR TTGILMGSKA VKPVLVKNIT IEGVAYTSEC FPCKPGTFSN KPGSFNCQVC PRNTYSEKGA KECIRCKDDS QFSEEGSSEC TERPPCTTKD YFQIHTPCDE EGKTQIMYKW IEPKICREDL TDAIRLPPSG EKKDCPPCNP GFYNNGSSSC HPCPPGTFSD GTKECRPCPA GTEPALGFEY KWWNVLPGNM KTSCFNVGNS KCDGMNGWEV AGDHIQSGAG GSDNDYLILN LHIPGFKPPT SMTGATGSEL GRITFVFETL CSADCVLYFM VDINRKSTNV VESWGGTKEK QAYTHIIFKN ATFTFTWAFQ RTNQGQDNRR FINDMVKIYS ITATNAVDGV ASSCRACALG SEQSGSSCVP CPPGHYIEKE TNQCKECPPD TYLSIHQVYG KEACIPCGPG SKNNQDHSVC YSDCFFYHEK ENQSLHYDFS NLSSVGSLMN GPSFTSKGTK YFHFFNISLC GHEGKKMALC TNNITDFTVK EIVAGSDDYT NLVGAFVCQS TIIPSESKGF RAALSSQSII LADTFIGVTV ETTLKNINIK EDMFPVPTSQ IPDVHFFYKS STATTSCING RSTAVKMRCN PTKSGAGVIS VPSKCPAGTC DGCTFYFLWE SAEACPLCTE HDFHEIEGAC KRGFQETLYV WNEPKWCIKG ISLPEKKLAT CETVDFWLKV GAGVGAFTAV LLVALTCYFW KKNQKLEYKY SKLVMTTNSK ECELPAADSC AIMEGEDNEE EVVYSNKQSL LGKLKSLATK EKEDHFESVQ LKTSRSPNI
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