About IQ motif and ankyrin repeat domain-containing protein 1
IQ motif and ankyrin repeat domain-containing protein 1 (IQANK1) is a protein
from Homo sapiens identified by UniProt accession
A8MXQ7, 560 residues long.
MolForge cross-references it against 0 known binders and
16 disease associations.
Target properties
| Protein name | IQ motif and ankyrin repeat domain-containing protein 1 |
|---|
| UniProt accession | A8MXQ7 |
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| Gene | IQANK1 |
|---|
| Organism | Homo sapiens |
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| Length | 560 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (16)
Diseases linked to this target (Open Targets).
- lean body mass · score 0.23
- fat body mass · score 0.20
- body weight · score 0.13
- whole body water mass · score 0.10
- age at menarche · score 0.08
- base metabolic rate measurement · score 0.08
- hip circumference · score 0.06
- body height · score 0.06
- appendicular lean mass · score 0.06
- brain measurement · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A8MXQ7-F1 | alphafold | PREDICTED | 79.56 | — |
Amino-acid sequence (560 residues)
MDSKKGRPKA AAGKWQTLHP GPKTRAAAGK PGENRPPQRK AGWQAREPAS AESPQAPTGP AEDRAARAIQ GAFRQLRARR ELARRREERR EYLEQMETPQ KEAYLAPVRR EQEAARRLRE QEEAAQRERR EELQRRRRLL DAAFDGDVGE IRAVLKEVEQ LLTREGVGHD EAGEARRLQR RVALAECEDS YGNTPLSEAA AGGQPLAIQL RAELGASPNS KGAFGPTPLY RAAFGGHLAA VEVLLKLGAD PRVYAEDGST PERVASLDTV VSVLRSWDLS LTEAMLQNME AEQQRRAQEA QRHKEAEAER CGSMTLKVQQ LTREQQQCHK ELQQAYCELS RRISEHDQCE WRCMDKTKLT LQAIKDTEAQ VDRLRQEAQK AEEALAMARL ELREQTQEGE EEAPGLKCQV TELHDVLMKD VGNRIRADGR WPLVIDPLGQ AATFLRYQDT NYVDTVNPEP LRPETMWLAL LGALRYGKPL VFDLREEDLF PVVQRQLEAV QERYLSLLRP TDGPEYSPTQ FQEQRLEHFR LFFVTKVQWP PAEQLQVLLP VRVQLPGTGL
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