About Forkhead box protein O6
Forkhead box protein O6 (FOXO6) is a protein
from Homo sapiens identified by UniProt accession
A8MYZ6, 492 residues long.
MolForge cross-references it against 0 known binders and
118 disease associations.
Target properties
| Protein name | Forkhead box protein O6 |
|---|
| UniProt accession | A8MYZ6 |
|---|
| Gene | FOXO6 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 492 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (118)
Diseases linked to this target (Open Targets).
- vitamin D measurement · score 0.47
- intelligence · score 0.45
- self reported educational attainment · score 0.45
- mathematical ability · score 0.45
- cognitive function measurement · score 0.41
- systolic blood pressure · score 0.35
- smoking status measurement · score 0.33
- creatinine measurement · score 0.32
- schizophrenia · score 0.31
- neurodegenerative disease · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A8MYZ6-F1 | alphafold | PREDICTED | 56.75 | — |
Amino-acid sequence (492 residues)
MAAKLRAHQV DVDPDFAPQS RPRSCTWPLP QPDLAGDEDG ALGAGVAEGA EDCGPERRAT APAMAPAPPL GAEVGPLRKA KSSRRNAWGN LSYADLITKA IESAPDKRLT LSQIYDWMVR YVPYFKDKGD SNSSAGWKNS IRHNLSLHTR FIRVQNEGTG KSSWWMLNPE GGKTGKTPRR RAVSMDNGAK FLRIKGKASK KKQLQAPERS PDDSSPSAPA PGPVPAAAKW AASPASHASD DYEAWADFRG GGRPLLGEAA ELEDDEALEA LAPSSPLMYP SPASALSPAL GSRCPGELPR LAELGGPLGL HGGGGAGLPE GLLDGAQDAY GPRPAPRPGP VLGAPGELAL AGAAAAYPGK GAAPYAPPAP SRSALAHPIS LMTLPGEAGA AGLAPPGHAA AFGGPPGGLL LDALPGPYAA AAAGPLGAAP DRFPADLDLD MFSGSLECDV ESIILNDFMD SDEMDFNFDS ALPPPPPGLA GAPPPNQSWV PG
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