About Lysine-specific demethylase 4E
Lysine-specific demethylase 4E (KDM4E) is a protein
from Homo sapiens identified by UniProt accession
B2RXH2, 506 residues long.
MolForge cross-references it against 0 known binders and
15 disease associations.
Target properties
| Protein name | Lysine-specific demethylase 4E |
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| UniProt accession | B2RXH2 |
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| Gene | KDM4E |
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| Organism | Homo sapiens |
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| Length | 506 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (5)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (15)
Diseases linked to this target (Open Targets).
- breast ductal adenocarcinoma · score 0.11
- electrocardiography · score 0.04
- progesterone measurement · score 0.03
- aspartate aminotransferase measurement · score 0.03
- body height · score 0.02
- triple-negative breast cancer · score 0.02
- nail-patella syndrome · score 0.01
- atrial fibrillation · score 0.01
- infarction · score 0.01
- cancer · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-B2RXH2-F1 | alphafold | PREDICTED | 75.49 | — |
Amino-acid sequence (506 residues)
MKSVHSSPQN TSHTIMTFYP TMEEFADFNT YVAYMESQGA HQAGLAKVIP PKEWKARQMY DDIEDILIAT PLQQVTSGQG GVFTQYHKKK KAMRVGQYRR LANSKKYQTP PHQNFADLEQ RYWKSHPGNP PIYGADISGS LFEESTKQWN LGHLGTILDL LEQECGVVIE GVNTPYLYFG MWKTTFAWHT EDMDLYSINY LHFGEPKTWY VVPPEHGQHL ERLARELFPD ISRGCEAFLR HKVALISPTV LKENGIPFNC MTQEAGEFMV TFPYGYHAGF NHGFNCAEAI NFATPRWIDY GKMASQCSCG ESTVTFSMDP FVRIVQPESY ELWKHRQDLA IVEHTEPRVA ESQELSNWRD DIVLRRAALG LRLLPNLTAQ CPTQPVSSGH CYNPKGCGTD AVPGSAFQSS AYHTQTQSLT LGMSARVLLP STGSWGSGRG RGRGQGQGRG CSRGRGHGCC TRELGTEEPT VQPASKRRLL MGTRSRAQGH RPQLPLANDL MTNLSL
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