About Transmembrane protein 114
Transmembrane protein 114 (TMEM114) is a protein
from Homo sapiens identified by UniProt accession
B3SHH9, 223 residues long.
MolForge cross-references it against 0 known binders and
13 disease associations.
Target properties
| Protein name | Transmembrane protein 114 |
|---|
| UniProt accession | B3SHH9 |
|---|
| Gene | TMEM114 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 223 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (13)
Diseases linked to this target (Open Targets).
- vital capacity · score 0.49
- forced expiratory volume · score 0.37
- autoimmune thyroid disease · score 0.26
- refractive error · score 0.13
- chronotype measurement · score 0.13
- monocyte count · score 0.13
- sphingomyelin measurement · score 0.08
- body mass index · score 0.06
- adrenocortical carcinoma, hereditary · score 0.00
- Hyperglycemia · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-B3SHH9-F1 | alphafold | PREDICTED | 82.11 | — |
Amino-acid sequence (223 residues)
MRVHLGGLAG AAALTGALSF VLLAAAIGTD FWYIIDTERL ERTGPGAQDL LGSINRSQPE PLSSHSGLWR TCRVQSPCTP LMNPFRLENV TVSESSRQLL TMHGTFVILL PLSLILMVFG GMTGFLSFLL QAYLLLLLTG ILFLFGAMVT LAGISVYIAY SAAAFREALC LLEEKALLDQ VDISFGWSLA LGWISFIAEL LTGAAFLAAA RELSLRRRQD QAI
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