About T-cell-interacting, activating receptor on myeloid cells protein 1
T-cell-interacting, activating receptor on myeloid cells protein 1 (TARM1) is a protein
from Homo sapiens identified by UniProt accession
B6A8C7, 271 residues long.
MolForge cross-references it against 0 known binders and
141 disease associations.
Target properties
| Protein name | T-cell-interacting, activating receptor on myeloid cells protein 1 |
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| UniProt accession | B6A8C7 |
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| Gene | TARM1 |
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| Organism | Homo sapiens |
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| Length | 271 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (141)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.23
- common variable immunodeficiency · score 0.06
- isolated agammaglobulinemia · score 0.06
- blood protein measurement · score 0.06
- severe combined immunodeficiency due to CARD11 deficiency · score 0.05
- severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive · score 0.05
- immunodeficiency 18 · score 0.05
- hyper-IgE recurrent infection syndrome 5, autosomal recessive · score 0.05
- T-B+ severe combined immunodeficiency due to JAK3 deficiency · score 0.05
- gamma chain deficiency · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-B6A8C7-F1 | alphafold | PREDICTED | 84.40 | — |
Amino-acid sequence (271 residues)
MIPKLLSLLC FRLCVGQGDT RGDGSLPKPS LSAWPSSVVP ANSNVTLRCW TPARGVSFVL RKGGIILESP KPLDSTEGAA EFHLNNLKVR NAGEYTCEYY RKASPHILSQ HSDVLLLLVT GHLSKPFLRT YQRGTVTAGG RVTLQCQKRD QLFVPIMFAL LKAGTPSPIQ LQSPAGKEID FSLVDVTAGD AGNYSCMYYQ TKSPFWASEP SDQLEILVTV PPGTTSSNYS LGNFVRLGLA AVIVVIMGAF LVEAWYSRNV SPGESEAFKP E
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