Tripartite motif-containing protein 49D (TRIM49D1)

About Tripartite motif-containing protein 49D

Tripartite motif-containing protein 49D (TRIM49D1) is a protein from Homo sapiens identified by UniProt accession C9J1S8, 452 residues long. MolForge cross-references it against 0 known binders and 9 disease associations.

Target properties

Protein name	Tripartite motif-containing protein 49D
UniProt accession	C9J1S8
Gene	TRIM49D1
Organism	Homo sapiens
Length	452 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (9)

Diseases linked to this target (Open Targets).

basophil count · score 0.36
basophil percentage of granulocytes · score 0.06
smoking status measurement · score 0.04
basophil percentage of leukocytes · score 0.04
adolescent idiopathic scoliosis · score 0.03
pulse pressure measurement · score 0.03
homocysteine measurement · score 0.03
sunburn · score 0.03
hair colour measurement · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-C9J1S8-F1	alphafold	PREDICTED	85.68	—

Amino-acid sequence (452 residues)

MNSGISQVFQ RELTCPICLN YFIDPVTIDC GHSFCRPCFY LNWQDIPILT QCFECLKTTQ QRNLKTNIRL KKMASRARKA SLWLFLSSEE QMCGTHRETK KIFCEVDRSL LCLLCSSSLE HRYHRHCPAE WAAEEHREKL LKKMQSLWEK VCENQRNLNV ETTRISHWKD YVNVRLEAIR AEYQKMPAFH HEEEKHNLEM LKKKGKDIFH RLHLSKAKMA HRREILRGTY AELMKMCHKP DVELLQAFGD ILHRSESVLL HMPQPLNLEL RAGPITGLRD RLNQFRVDIT LPHNEANSHI FRRGDLRSIC IGCDRQNAPH ITATPTSFLA WGAQTFTSGK YYWEVHVGDS WNWAFGVCNK YWKGTNQNGN IHGEEGLFSL GCVKNDIQCS LFTTSPLTLQ YVPRPTNHVG LFLDCEARTV SFVDVNQSSP IHTIPNCSFS PPLRPIFCCV HL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards