About Ubiquitin carboxyl-terminal hydrolase 17-like protein 10
Ubiquitin carboxyl-terminal hydrolase 17-like protein 10 (USP17L10) is a protein
from Homo sapiens identified by UniProt accession
C9JJH3, 530 residues long.
MolForge cross-references it against 0 known binders and
22 disease associations.
Target properties
| Protein name | Ubiquitin carboxyl-terminal hydrolase 17-like protein 10 |
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| UniProt accession | C9JJH3 |
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| Gene | USP17L10 |
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| Organism | Homo sapiens |
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| Length | 530 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (22)
Diseases linked to this target (Open Targets).
- immunodeficiency 19 · score 0.04
- combined immunodeficiency with skin granulomas · score 0.03
- urate measurement · score 0.03
- immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia · score 0.03
- severe combined immunodeficiency due to IKK2 deficiency · score 0.03
- ring chromosome Y · score 0.03
- X-Linked Combined Immunodeficiency Diseases · score 0.03
- severe combined immunodeficiency due to LAT deficiency · score 0.03
- obesity due to congenital leptin deficiency · score 0.03
- immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-C9JJH3-F1 | alphafold | PREDICTED | 67.10 | — |
Amino-acid sequence (530 residues)
MEDDSLYLGG EWQFNHFSKL TSSRPDAAFA EIQRTSLPEK SPLSCETRVD LCDDLAPVAR QLAPREKPPL SSRRPAAVGA GLQNMGNTCY VNASLQCLTY KPPLANYMLF REHSQTCHRH KGCMLCTMQA HITRALHIPG HVIQPSQALA AGFHRGKQED AHEFLMFTVD AMRKACLPGH KQVDRHSKDT TLIHQIFGGY WRSQIKCLHC HGISDTFDPY LDIALDIQAA QSVQQALEQL VKPEELNGEN AYHCGVCLQR APASKTLTLH NSAKVLILVL KRFPDVTGNK IAKNVQYPEC LDMQPYMSQQ NTGPLVYVLY AVLVHAGWSC HNGHYSSYVK AQEGQWYKMD DAEVTASSIT SVLSQQAYVL FYIQKSEWER HSESVSRGRE PRALGVEDTD RRATQGELKR DHPCLQAPEL DEHLVERATQ ESTLDHWKFL QEQNKTKPEF NVRRVEGTVP PDVLVIHQSK YKCRMKNHHP EQQSSLLNLS STTPTDQESM NTGTLASLRG RTRRSKGKNK HSKRALLVCQ
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