About Transmembrane protein 178B
Transmembrane protein 178B (TMEM178B) is a protein
from Homo sapiens identified by UniProt accession
H3BS89, 294 residues long.
MolForge cross-references it against 0 known binders and
46 disease associations.
Target properties
| Protein name | Transmembrane protein 178B |
|---|
| UniProt accession | H3BS89 |
|---|
| Gene | TMEM178B |
|---|
| Organism | Homo sapiens |
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| Length | 294 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (46)
Diseases linked to this target (Open Targets).
- bone density · score 0.24
- urate measurement · score 0.24
- forced expiratory volume · score 0.20
- urticaria · score 0.10
- bipolar disorder · score 0.08
- schizophrenia · score 0.07
- hypotrichosis simplex · score 0.06
- balding measurement · score 0.06
- vital capacity · score 0.06
- BMI-adjusted waist circumference · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-H3BS89-F1 | alphafold | PREDICTED | 75.45 | — |
Amino-acid sequence (294 residues)
MAAGRLLLYT GLSLALCALG MLAVAICSDH WYETDARKHR DRCKAFNTRR VDPGFIYNNN NNLPLRASRS RLDRWEGKLL RARNRRQLFA MSPADECSRQ YNSTNMGLWR KCHRQGFDPE IAALIRKGEI ERCTYIKYHY SSATIPRNLT FNITKTIRQD EWHALHLRRM TAGFMGMAVA IILFGWIIGV LGCCWDRGLM QYVAGLLFLM GGTFCIISLC TCVAGINFEL SRYPRYLYGL PDDISHGYGW SMFCAWGGLG LTLISGFFCT LAPSVQPVPR TNYPKSRPEN GTVC
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