Tripartite motif-containing protein 77 (TRIM77)

About Tripartite motif-containing protein 77

Tripartite motif-containing protein 77 (TRIM77) is a protein from Homo sapiens identified by UniProt accession I1YAP6, 450 residues long. MolForge cross-references it against 0 known binders and 27 disease associations.

Target properties

Protein name	Tripartite motif-containing protein 77
UniProt accession	I1YAP6
Gene	TRIM77
Organism	Homo sapiens
Length	450 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (27)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.29
forced expiratory volume · score 0.11
lean body mass · score 0.10
vital capacity · score 0.09
body height · score 0.08
hemolytic anemia · score 0.08
fat body mass · score 0.08
base metabolic rate measurement · score 0.07
diabetic retinopathy · score 0.06
whole body water mass · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-I1YAP6-F1	alphafold	PREDICTED	81.58	—

Amino-acid sequence (450 residues)

MASAITQCST SELTCSICTD YLTDPVTICC GHRFCSPCLC LLWEDTLTPN CCPVCREISQ QMYFKRIIFA EKQVIPTRES VPCQLSSSAM LICRRHQEIK NLICETDRSL LCFLCSQSPR HATHKHYMTR EADEYYRKKL LIQMKSIWKK KQKNQRNLNR ETNIIGTWEV FINLRSMMIS AEYPKVCQYL REEEQKHVES LAREGRIIFQ QLKRSQTRMA KMGILLREMY EKLKEMSCKA DVNLPQDLGD VMKRNEFLRL AMPQPVNPQL SAWTITGVSE RLNFFRVYIT LDRKICSNHK LLFEDLRHLQ CSLDDTDMSC NPTSTQYTSS WGAQILSSGK HYWEVDVKDS CNWVIGLCRE AWTKRNDMRL DSEGIFLLLC LKVDDHFSLF STSPLLPHYI PRPQGWLGVF LDYECGIVSF VNVAQSSLIC SFLSRIFYFP LRPFICHGSK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards