Suppressyn (ERVH48-1)

About Suppressyn

Suppressyn (ERVH48-1) is a protein from Homo sapiens identified by UniProt accession M5A8F1, 160 residues long. MolForge cross-references it against 0 known binders and 20 disease associations.

Target properties

Protein name	Suppressyn
UniProt accession	M5A8F1
Gene	ERVH48-1
Organism	Homo sapiens
Length	160 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (20)

Diseases linked to this target (Open Targets).

Down syndrome · score 0.05
acute myeloid leukemia · score 0.04
trisomy 21 · score 0.01
Ataxia-telangiectasia · score 0.01
neoplasm · score 0.01
lung adenocarcinoma · score 0.00
prostate carcinoma · score 0.00
endometrium adenocarcinoma · score 0.00
perinatal disease · score 0.00
infect · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-M5A8F1-F1	alphafold	PREDICTED	74.97	—

Amino-acid sequence (160 residues)

MACIYPTTFY TSLPTKSLNM GISLTTILIL SVAVLLSTAA PPSCRECYQS LHYRGEMQQY FTYHTHIERS CYGNLIEECV ESGKSYYKVK NLGVCGSRNG AICPRGKQWL CFTKIGQWGV NTQVLEDIKR EQIIAKAKAS KPTTPPENRP RHFHSFIQKL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards