Thymidine kinase 2, mitochondrial (TK2)

About Thymidine kinase 2, mitochondrial

Thymidine kinase 2, mitochondrial (TK2) is a protein from Homo sapiens identified by UniProt accession O00142, 265 residues long. MolForge cross-references it against 0 known binders and 70 disease associations.

Target properties

Protein name	Thymidine kinase 2, mitochondrial
UniProt accession	O00142
Gene	TK2
Organism	Homo sapiens
Length	265 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (70)

Diseases linked to this target (Open Targets).

mitochondrial DNA depletion syndrome, myopathic form · score 0.83
mitochondrial DNA depletion syndrome · score 0.69
progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 3 · score 0.69
neurodegenerative disease · score 0.42
autosomal recessive progressive external ophthalmoplegia · score 0.37
mitochondrial disease · score 0.37
myopathy · score 0.34
Abnormality of the musculature · score 0.27
endometrial cancer · score 0.24
lysosomal storage disease · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00142-F1	alphafold	PREDICTED	84.72	—

Amino-acid sequence (265 residues)

MLLWPLRGWA ARALRCFGPG SRGSPASGPG PRRVQRRAWP PDKEQEKEKK SVICVEGNIA SGKTTCLEFF SNATDVEVLT EPVSKWRNVR GHNPLGLMYH DASRWGLTLQ TYVQLTMLDR HTRPQVSSVR LMERSIHSAR YIFVENLYRS GKMPEVDYVV LSEWFDWILR NMDVSVDLIV YLRTNPETCY QRLKKRCREE EKVIPLEYLE AIHHLHEEWL IKGSLFPMAA PVLVIEADHH MERMLELFEQ NRDRILTPEN RKHCP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards