About Protein phosphatase EYA2
Protein phosphatase EYA2 (EYA2) is a protein
from Homo sapiens identified by UniProt accession
O00167, 538 residues long.
MolForge cross-references it against 0 known binders and
217 disease associations.
Target properties
| Protein name | Protein phosphatase EYA2 |
|---|
| UniProt accession | O00167 |
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| Gene | EYA2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 538 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (217)
Diseases linked to this target (Open Targets).
- heel bone mineral density · score 0.53
- BMI-adjusted waist-hip ratio · score 0.53
- triglyceride measurement · score 0.51
- waist-hip ratio · score 0.50
- bone quantitative ultrasound measurement · score 0.50
- type 2 diabetes mellitus · score 0.46
- BMI-adjusted hip circumference · score 0.46
- sex hormone-binding globulin measurement · score 0.46
- BMI-adjusted waist circumference · score 0.45
- vital capacity · score 0.45
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O00167-F1 | alphafold | PREDICTED | 68.01 | — |
Amino-acid sequence (538 residues)
MVELVISPSL TVNSDCLDKL KFNRADAAVW TLSDRQGITK SAPLRVSQLF SRSCPRVLPR QPSTAMAAYG QTQYSAGIQQ ATPYTAYPPP AQAYGIPSYS IKTEDSLNHS PGQSGFLSYG SSFSTSPTGQ SPYTYQMHGT TGFYQGGNGL GNAAGFGSVH QDYPSYPGFP QSQYPQYYGS SYNPPYVPAS SICPSPLSTS TYVLQEASHN VPNQSSESLA GEYNTHNGPS TPAKEGDTDR PHRASDGKLR GRSKRSSDPS PAGDNEIERV FVWDLDETII IFHSLLTGTF ASRYGKDTTT SVRIGLMMEE MIFNLADTHL FFNDLEDCDQ IHVDDVSSDD NGQDLSTYNF SADGFHSSAP GANLCLGSGV HGGVDWMRKL AFRYRRVKEM YNTYKNNVGG LIGTPKRETW LQLRAELEAL TDLWLTHSLK ALNLINSRPN CVNVLVTTTQ LIPALAKVLL YGLGSVFPIE NIYSATKTGK ESCFERIMQR FGRKAVYVVI GDGVEEEQGA KKHNMPFWRI SCHADLEALR HALELEYL
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