Benzbromarone

MUSCULO-SKELETAL SYSTEM

Key facts

Benzbromarone is a drug catalogued in DrugCentral. DrugCentral lists 25 molecular targets, including TTR, CYP2C9 and SLC22A12. Recorded indications include Gout and Hyperuricemia.

• Molecular targets: TTR, CYP2C9, SLC22A12 and AKR1C1 (25 listed in DrugCentral).
• Indications: Gout and Hyperuricemia.
• ATC code: M04AB03 (Preparations increasing uric acid excretion).
• Molecular formula: C17H12Br2O3; molecular weight 424.09 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (2)

• Gout
• Hyperuricemia

Mechanism & targets

Molecular targets (25)

Target	Gene	Action	Activity
Transthyretin	TTR	unknown	Kd 7.82
Cytochrome P450 2C9	CYP2C9	unknown	IC50 7.80
Solute carrier family 22 member 12	SLC22A12	inhibitor	IC50 7.59
Aldo-keto reductase family 1 member C1	AKR1C1	unknown	IC50 7.32
Multidrug resistance-associated protein 1	ABCC1	unknown	Ki 6.72
ATP-binding cassette sub-family G member 2	ABCG2	unknown	IC50 6.70
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	unknown	IC50 5.98
5-hydroxytryptamine receptor 2B	HTR2B	unknown	Ki 5.94
Mitogen-activated protein kinase 14	MAPK14	unknown	IC50 5.91
Mitogen-activated protein kinase 1	MAPK1	unknown	IC50 5.71
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	PDE4D	unknown	IC50 5.68
Solute carrier family 22 member 6	SLC22A6	unknown	IC50 5.67
Adenosine receptor A3	ADORA3	unknown	Ki 5.53
Piezo-type mechanosensitive ion channel component 1	PIEZO1	inhibitor	IC50 5.40
Eyes absent homolog 3	EYA3	unknown	IC50 5.08
Thyroid hormone receptor beta	THRB	unknown	Kd 5.05
Eyes absent homolog 2	EYA2	unknown	IC50 4.99
Eyes absent homolog 3	Eya3	unknown	IC50 4.96
Envelope glycoprotein gp160	env	unknown	IC50 4.89
Envelope glycoprotein gp160 [Cleaved into: Surface protein gp120	env	unknown	IC50 4.89

ATC classification

ATC code	Therapeutic hierarchy
M04AB03	MUSCULO-SKELETAL SYSTEM › ANTIGOUT PREPARATIONS › ANTIGOUT PREPARATIONS › Preparations increasing uric acid excretion

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Renal impairment	96.5
Hepatic function abnormal	53.7
Interstitial lung disease	32.3
White blood cell count decreased	29.0

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Benzbromarone is on its molecule page.

• Molecular formula: C₁₇H₁₂Br₂O₃
• Molecular weight: 424.09 g/mol
• CAS number: 3562-84-3
• InChIKey: WHQCHUCQKNIQEC-UHFFFAOYSA-N
• PubChem CID: 2333

CCC1=C(C(=O)C2=CC(Br)=C(O)C(Br)=C2)C2=C(O1)C=CC=C2

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Benzbromarone used for?

DrugCentral lists the following indications for Benzbromarone: Gout and Hyperuricemia.

How does Benzbromarone work?

Its molecular targets in DrugCentral include TTR, CYP2C9, SLC22A12 (inhibitor) and AKR1C1.

What is the chemical formula of Benzbromarone?

Benzbromarone has the molecular formula C17H12Br2O3 and a molecular weight of 424.09 g/mol.

Sources

• DrugCentral drug card 318 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL388590 — compound record and bioactivity
• PubChem CID 2333 — chemical identifiers
• DrugBank DB12319 — drug record
• FDA UNII 4POG0RL69O — substance identity
• UniProt P02766 (TTR) — target protein
• UniProt P11712 (CYP2C9) — target protein
• UniProt Q96S37 (SLC22A12) — target protein
• UniProt Q04828 (AKR1C1) — target protein
• UniProt P33527 (ABCC1) — target protein
• UniProt Q9UNQ0 (ABCG2) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.