About Cytochrome P450 2C9
Cytochrome P450 2C9 (CYP2C9) is a protein
from Homo sapiens identified by UniProt accession
P11712, 490 residues long.
MolForge cross-references it against 0 known binders and
308 disease associations.
Target properties
| Protein name | Cytochrome P450 2C9 |
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| UniProt accession | P11712 |
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| Gene | CYP2C9 |
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| Organism | Homo sapiens |
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| Length | 490 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (308)
Diseases linked to this target (Open Targets).
- cholesterol embolism · score 0.45
- response to anticoagulant · score 0.43
- trait in response to phenytoin · score 0.42
- blood metabolite measurement · score 0.38
- serum metabolite measurement · score 0.34
- lymphocyte count · score 0.32
- appendicular lean mass · score 0.30
- alkaline phosphatase measurement · score 0.29
- leukocyte count · score 0.26
- cutaneous melanoma · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P11712-F1 | alphafold | PREDICTED | 92.95 | — |
Amino-acid sequence (490 residues)
MDSLVVLVLC LSCLLLLSLW RQSSGRGKLP PGPTPLPVIG NILQIGIKDI SKSLTNLSKV YGPVFTLYFG LKPIVVLHGY EAVKEALIDL GEEFSGRGIF PLAERANRGF GIVFSNGKKW KEIRRFSLMT LRNFGMGKRS IEDRVQEEAR CLVEELRKTK ASPCDPTFIL GCAPCNVICS IIFHKRFDYK DQQFLNLMEK LNENIKILSS PWIQICNNFS PIIDYFPGTH NKLLKNVAFM KSYILEKVKE HQESMDMNNP QDFIDCFLMK MEKEKHNQPS EFTIESLENT AVDLFGAGTE TTSTTLRYAL LLLLKHPEVT AKVQEEIERV IGRNRSPCMQ DRSHMPYTDA VVHEVQRYID LLPTSLPHAV TCDIKFRNYL IPKGTTILIS LTSVLHDNKE FPNPEMFDPH HFLDEGGNFK KSKYFMPFSA GKRICVGEAL AGMELFLFLT SILQNFNLKS LVDPKNLDTT PVVNGFASVP PFYQLCFIPV
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