Suprofen

MUSCULO-SKELETAL SYSTEM

Key facts

Suprofen is an ofm drug catalogued in DrugCentral. It was first approved by the FDA in 1988. DrugCentral lists 3 molecular targets, including PTGS1, PTGS2 and CYP2C9.

• Approval status: ofm (first approved 1988 by the FDA).
• Molecular targets: PTGS1, PTGS2 and CYP2C9 (3 listed in DrugCentral).
• ATC code: M01AE07 (Propionic acid derivatives).
• Molecular formula: C14H12O3S; molecular weight 260.31 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Contraindications (2)

• Blood coagulation disorder
• Herpes simplex dendritic keratitis

Mechanism & targets

Molecular targets (3)

Target	Gene	Action	Activity
Prostaglandin G/H synthase 1	PTGS1	inhibitor	IC50 5.96
Prostaglandin G/H synthase 2	PTGS2	inhibitor	IC50 5.06
Cytochrome P450 2C9	CYP2C9	unknown	Ki 4.35

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1988-12-23	FDA	—	ALCON

ATC classification

ATC code	Therapeutic hierarchy
M01AE07	MUSCULO-SKELETAL SYSTEM › ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS › ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS › Propionic acid derivatives

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Suprofen is on its molecule page.

• Molecular formula: C₁₄H₁₂O₃S
• Molecular weight: 260.31 g/mol
• CAS number: —
• InChIKey: MDKGKXOCJGEUJW-UHFFFAOYSA-N
• PubChem CID: 5359

CC(C(O)=O)C1=CC=C(C=C1)C(=O)C1=CC=CS1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Suprofen work?

Its molecular targets in DrugCentral include PTGS1 (inhibitor), PTGS2 (inhibitor) and CYP2C9.

When was Suprofen first approved?

Suprofen was first approved by the FDA in 1988.

What is the chemical formula of Suprofen?

Suprofen has the molecular formula C14H12O3S and a molecular weight of 260.31 g/mol.

Sources

• DrugCentral drug card 2546 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL956 — compound record and bioactivity
• PubChem CID 5359 — chemical identifiers
• DrugBank DB00870 — drug record
• FDA UNII 988GU2F9PE — substance identity
• DailyMed: FDA labels for Suprofen — current prescribing information (label search)
• UniProt P23219 (PTGS1) — target protein
• UniProt P35354 (PTGS2) — target protein
• UniProt P11712 (CYP2C9) — target protein

How this page is built: methodology · editorial policy & corrections.