About Prostaglandin G/H synthase 2
Prostaglandin G/H synthase 2 (PTGS2) is a protein
from Homo sapiens identified by UniProt accession
P35354, 604 residues long.
MolForge cross-references it against 0 known binders and
1,813 disease associations.
Target properties
| Protein name | Prostaglandin G/H synthase 2 |
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| UniProt accession | P35354 |
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| Gene | PTGS2 |
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| Organism | Homo sapiens |
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| Length | 604 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (1813)
Diseases linked to this target (Open Targets).
- rheumatoid arthritis · score 0.64
- migraine disorder · score 0.63
- gout · score 0.63
- ulcerative colitis · score 0.63
- osteoarthritis · score 0.62
- coronary artery disease · score 0.62
- Headache · score 0.61
- Dysmenorrhea · score 0.61
- pain · score 0.61
- ankylosing spondylitis · score 0.61
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P35354-F1 | alphafold | PREDICTED | 93.02 | — |
Amino-acid sequence (604 residues)
MLARALLLCA VLALSHTANP CCSHPCQNRG VCMSVGFDQY KCDCTRTGFY GENCSTPEFL TRIKLFLKPT PNTVHYILTH FKGFWNVVNN IPFLRNAIMS YVLTSRSHLI DSPPTYNADY GYKSWEAFSN LSYYTRALPP VPDDCPTPLG VKGKKQLPDS NEIVEKLLLR RKFIPDPQGS NMMFAFFAQH FTHQFFKTDH KRGPAFTNGL GHGVDLNHIY GETLARQRKL RLFKDGKMKY QIIDGEMYPP TVKDTQAEMI YPPQVPEHLR FAVGQEVFGL VPGLMMYATI WLREHNRVCD VLKQEHPEWG DEQLFQTSRL ILIGETIKIV IEDYVQHLSG YHFKLKFDPE LLFNKQFQYQ NRIAAEFNTL YHWHPLLPDT FQIHDQKYNY QQFIYNNSIL LEHGITQFVE SFTRQIAGRV AGGRNVPPAV QKVSQASIDQ SRQMKYQSFN EYRKRFMLKP YESFEELTGE KEMSAELEAL YGDIDAVELY PALLVEKPRP DAIFGETMVE VGAPFSLKGL MGNVICSPAY WKPSTFGGEV GFQIINTASI QSLICNNVKG CPFTSFSVPD PELIKTVTIN ASSSRSGLDD INPTVLLKER STEL
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