Oxaprozin

Nonsteroidal Anti-inflammatory Drug — MUSCULO-SKELETAL SYSTEM

Key facts

Oxaprozin is an ofp drug in the Nonsteroidal Anti-inflammatory Drug class catalogued in DrugCentral. It was first approved by the FDA in 1992. Its mechanism of action is classified as Cyclooxygenase Inhibitors. DrugCentral lists 14 molecular targets, including C5, PTGS1 and SHMT2. Recorded indications include Juvenile rheumatoid arthritis, Osteoarthritis and Rheumatoid arthritis.

• Approval status: ofp (first approved 1992 by the FDA).
• Drug class: Nonsteroidal Anti-inflammatory Drug.
• Mechanism of action: Cyclooxygenase Inhibitors.
• Molecular targets: C5, PTGS1, SHMT2 and EPHX2 (14 listed in DrugCentral).
• Indications: Juvenile rheumatoid arthritis, Osteoarthritis and Rheumatoid arthritis.
• ATC code: M01AE12 (Propionic acid derivatives).
• Molecular formula: C18H15NO3; molecular weight 293.32 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (3)

• Juvenile rheumatoid arthritis
• Osteoarthritis
• Rheumatoid arthritis

Off-label uses (1)

• Ankylosing spondylitis

Contraindications (14)

• Blood coagulation disorder
• Cardiovascular event risk
• Chronic heart failure
• Coronary artery bypass graft
• Disorder of cardiovascular system
• Gastrointestinal hemorrhage
• Gastrointestinal ulcer
• Hepatic failure
• Hypertensive disorder
• Kidney disease
• Myocardial infarction
• Peptic ulcer
• Pregnancy, function
• Smokes tobacco daily

Mechanism & targets

• Mechanism of action (MoA): Cyclooxygenase Inhibitors
• Established pharmacologic class: Nonsteroidal Anti-inflammatory Drug

Molecular targets (14)

Target	Gene	Action	Activity
Complement C5	C5	unknown	Kd 6.19
Prostaglandin G/H synthase 1	PTGS1	inhibitor	IC50 6.07
Serine hydroxymethyltransferase, mitochondrial	SHMT2	unknown	IC50 5.71
Bifunctional epoxide hydrolase 2	EPHX2	inhibitor	IC50 5.30
Nuclear receptor subfamily 4 group A member 1	NR4A1	unknown	IC50 4.80
Retinoic acid receptor RXR-alpha	RXRA	unknown	EC50 4.79
Nuclear receptor subfamily 4 group A member 3	NR4A3	unknown	IC50 4.66
Retinoic acid receptor RXR-beta	RXRB	unknown	EC50 4.60
Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2	Ephx2	unknown	IC50 4.45
Prostaglandin G/H synthase 2	PTGS2	inhibitor	IC50 4.44
Nuclear receptor subfamily 4 group A member 2	NR4A2	unknown	IC50 4.40
Retinoic acid receptor RXR-gamma	RXRG	unknown	EC50 4.40
Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2	Ephx2	unknown	IC50 4.20
fMet-Leu-Phe receptor	FPR1	unknown	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1992-10-29	FDA	—	GD SEARLE

ATC classification

ATC code	Therapeutic hierarchy
M01AE12	MUSCULO-SKELETAL SYSTEM › ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS › ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS › Propionic acid derivatives

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Drug hypersensitivity	704.7
General symptom	32.3

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Oxaprozin is on its molecule page.

• Molecular formula: C₁₈H₁₅NO₃
• Molecular weight: 293.32 g/mol
• CAS number: —
• InChIKey: OFPXSFXSNFPTHF-UHFFFAOYSA-N
• PubChem CID: 4614

OC(=O)CCC1=NC(=C(O1)C1=CC=CC=C1)C1=CC=CC=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Oxaprozin used for?

DrugCentral lists the following indications for Oxaprozin: Juvenile rheumatoid arthritis, Osteoarthritis and Rheumatoid arthritis.

How does Oxaprozin work?

Oxaprozin is classified as Cyclooxygenase Inhibitors; its molecular targets in DrugCentral include C5, PTGS1 (inhibitor), SHMT2 and EPHX2 (inhibitor).

When was Oxaprozin first approved?

Oxaprozin was first approved by the FDA in 1992.

What drug class does Oxaprozin belong to?

Oxaprozin is in the Nonsteroidal Anti-inflammatory Drug class.

What is the chemical formula of Oxaprozin?

Oxaprozin has the molecular formula C18H15NO3 and a molecular weight of 293.32 g/mol.

Sources

• DrugCentral drug card 2013 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1071 — compound record and bioactivity
• PubChem CID 4614 — chemical identifiers
• DrugBank DB00991 — drug record
• FDA UNII MHJ80W9LRB — substance identity
• DailyMed: FDA labels for Oxaprozin — current prescribing information (label search)
• UniProt P01031 (C5) — target protein
• UniProt P23219 (PTGS1) — target protein
• UniProt P34897 (SHMT2) — target protein
• UniProt P34913 (EPHX2) — target protein
• UniProt P22736 (NR4A1) — target protein
• UniProt P19793 (RXRA) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.