About Bifunctional epoxide hydrolase 2
Bifunctional epoxide hydrolase 2 (EPHX2) is a protein
from Homo sapiens identified by UniProt accession
P34913, 555 residues long.
MolForge cross-references it against 0 known binders and
376 disease associations.
Target properties
| Protein name | Bifunctional epoxide hydrolase 2 |
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| UniProt accession | P34913 |
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| Gene | EPHX2 |
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| Organism | Homo sapiens |
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| Length | 555 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (11)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (376)
Diseases linked to this target (Open Targets).
- protein measurement · score 0.35
- neurodegenerative disease · score 0.34
- smoking status measurement · score 0.32
- smoking initiation · score 0.32
- lung carcinoma · score 0.28
- schizophrenia · score 0.28
- chronic obstructive pulmonary disease · score 0.28
- cannabis dependence · score 0.28
- cigarettes per day measurement · score 0.24
- hypercholesterolemia, familial, 1 · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P34913-F1 | alphafold | PREDICTED | 93.32 | — |
Amino-acid sequence (555 residues)
MTLRAAVFDL DGVLALPAVF GVLGRTEEAL ALPRGLLNDA FQKGGPEGAT TRLMKGEITL SQWIPLMEEN CRKCSETAKV CLPKNFSIKE IFDKAISARK INRPMLQAAL MLRKKGFTTA ILTNTWLDDR AERDGLAQLM CELKMHFDFL IESCQVGMVK PEPQIYKFLL DTLKASPSEV VFLDDIGANL KPARDLGMVT ILVQDTDTAL KELEKVTGIQ LLNTPAPLPT SCNPSDMSHG YVTVKPRVRL HFVELGSGPA VCLCHGFPES WYSWRYQIPA LAQAGYRVLA MDMKGYGESS APPEIEEYCM EVLCKEMVTF LDKLGLSQAV FIGHDWGGML VWYMALFYPE RVRAVASLNT PFIPANPNMS PLESIKANPV FDYQLYFQEP GVAEAELEQN LSRTFKSLFR ASDESVLSMH KVCEAGGLFV NSPEEPSLSR MVTEEEIQFY VQQFKKSGFR GPLNWYRNME RNWKWACKSL GRKILIPALM VTAEKDFVLV PQMSQHMEDW IPHLKRGHIE DCGHWTQMDK PTEVNQILIK WLDSDARNPP VVSKM
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