Quercetin

Drug profile

Key facts

Quercetin is a drug catalogued in DrugCentral. DrugCentral lists 163 molecular targets, including MAOA, CYP19A1 and AKR1B1.

• Molecular targets: MAOA, CYP19A1, AKR1B1 and fabI (163 listed in DrugCentral).
• Molecular formula: C15H10O7; molecular weight 302.24 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Contraindications (5)

• Anemia due to enzyme deficiency
• Hb SS disease
• Hemochromatosis
• Kidney disease
• Primary hyperoxaluria

Mechanism & targets

Molecular targets (163)

Target	Gene	Action	Activity
Amine oxidase [flavin-containing] A	MAOA	unknown	IC50 8.00
Aromatase	CYP19A1	unknown	IC50 7.92
Aldose reductase	AKR1B1	unknown	IC50 7.83
Enoyl-acyl-carrier protein reductase	fabI	unknown	Ki 7.66
Serine/threonine-protein kinase pim-1	PIM1	unknown	Kd 7.60
Prothrombin	F2	unknown	Kd 7.41
5'-nucleotidase	Nt5e	unknown	Ki 7.34
Cytochrome P450 1B1	CYP1B1	unknown	IC50 7.11
Proto-oncogene tyrosine-protein kinase Src	SRC	unknown	IC50 6.92
Arachidonate 5-lipoxygenase	Alox5	unknown	IC50 6.70
Vascular endothelial growth factor receptor 2	KDR	unknown	IC50 6.55
Insulin-like growth factor 1 receptor	IGF1R	unknown	IC50 6.52
Arachidonate 15-lipoxygenase	ALOX15	unknown	IC50 6.37
Arachidonate 12-lipoxygenase, 12S-type	ALOX12	unknown	IC50 6.36
Cyclin-dependent kinase 1	CDK1	unknown	IC50 6.35
Tyrosine-protein kinase Yes	YES1	unknown	Ki 6.33
Hepatocyte growth factor receptor	MET	unknown	IC50 6.24
Receptor-type tyrosine-protein kinase FLT3	FLT3	unknown	IC50 6.23
Integrase	pol	unknown	IC50 6.22
NADPH oxidase 4	NOX4	unknown	IC50 6.17

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Drug ineffective for unapproved indication	60.7

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Quercetin is on its molecule page.

• Molecular formula: C₁₅H₁₀O₇
• Molecular weight: 302.24 g/mol
• CAS number: 117-39-5
• InChIKey: REFJWTPEDVJJIY-UHFFFAOYSA-N
• PubChem CID: 5280343

OC1=CC(O)=C2C(OC(=C(O)C2=O)C2=CC(O)=C(O)C=C2)=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Quercetin work?

Its molecular targets in DrugCentral include MAOA, CYP19A1, AKR1B1 and fabI.

What is the chemical formula of Quercetin?

Quercetin has the molecular formula C15H10O7 and a molecular weight of 302.24 g/mol.

Sources

• DrugCentral drug card 3514 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL50 — compound record and bioactivity
• PubChem CID 5280343 — chemical identifiers
• DrugBank DB04216 — drug record
• FDA UNII 9IKM0I5T1E — substance identity
• UniProt P11511 (CYP19A1) — target protein
• UniProt P15121 (AKR1B1) — target protein
• UniProt P11309 (PIM1) — target protein
• UniProt P00734 (F2) — target protein
• UniProt Q16678 (CYP1B1) — target protein
• UniProt P12931 (SRC) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.