Aromatase (CYP19A1)

About Aromatase

Aromatase (CYP19A1) is a protein from Homo sapiens identified by UniProt accession P11511, 503 residues long. MolForge cross-references it against 0 known binders and 1,037 disease associations.

Target properties

Protein name	Aromatase
UniProt accession	P11511
Gene	CYP19A1
Organism	Homo sapiens
Length	503 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (16)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (1037)

Diseases linked to this target (Open Targets).

aromatase deficiency · score 0.77
breast cancer · score 0.63
breast carcinoma · score 0.61
breast neoplasm · score 0.59
neoplasm · score 0.56
infertility · score 0.56
heel bone mineral density · score 0.55
body height · score 0.52
endometrial carcinoma · score 0.52
estradiol measurement · score 0.52

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P11511-F1	alphafold	PREDICTED	91.38	—

Amino-acid sequence (503 residues)

MVLEMLNPIH YNITSIVPEA MPAATMPVLL LTGLFLLVWN YEGTSSIPGP GYCMGIGPLI SHGRFLWMGI GSACNYYNRV YGEFMRVWIS GEETLIISKS SSMFHIMKHN HYSSRFGSKL GLQCIGMHEK GIIFNNNPEL WKTTRPFFMK ALSGPGLVRM VTVCAESLKT HLDRLEEVTN ESGYVDVLTL LRRVMLDTSN TLFLRIPLDE SAIVVKIQGY FDAWQALLIK PDIFFKISWL YKKYEKSVKD LKDAIEVLIA EKRRRISTEE KLEECMDFAT ELILAEKRGD LTRENVNQCI LEMLIAAPDT MSVSLFFMLF LIAKHPNVEE AIIKEIQTVI GERDIKIDDI QKLKVMENFI YESMRYQPVV DLVMRKALED DVIDGYPVKK GTNIILNIGR MHRLEFFPKP NEFTLENFAK NVPYRYFQPF GFGPRGCAGK YIAMVMMKAI LVTLLRRFHV KTLQGQCVES IQKIHDLSLH PDETKNMLEM IFTPRNSDRC LEH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards