Linoleic acid

Drug profile

Key facts

Linoleic acid is a drug catalogued in DrugCentral. DrugCentral lists 17 molecular targets, including FABP3, PPARA and AKR1C3.

• Molecular targets: FABP3, PPARA, AKR1C3 and FABP4 (17 listed in DrugCentral).
• Molecular formula: C18H32O2; molecular weight 280.45 g/mol.

Mechanism & targets

Molecular targets (17)

Target	Gene	Action	Activity
Fatty acid-binding protein, heart	FABP3	unknown	Kd 9.70
Peroxisome proliferator-activated receptor alpha	PPARA	unknown	Kd 8.32
Aldo-keto reductase family 1 member C3	AKR1C3	unknown	IC50 6.16
Fatty acid-binding protein, adipocyte	FABP4	unknown	IC50 6.00
Seed linoleate 13S-lipoxygenase-1	LOX1.1	unknown	IC50 6.00
Free fatty acid receptor 4	FFAR4	agonist	EC50 5.89
Free fatty acid receptor 1	FFAR1	agonist	EC50 5.70
Potassium voltage-gated channel subfamily B member 1	KCNB1	activator	EC50 5.60
Peroxisome proliferator-activated receptor gamma	PPARG	unknown	IC50 5.21
Peroxisome proliferator-activated receptor delta	PPARD	unknown	IC50 5.00
Prostaglandin G/H synthase 1	PTGS1	unknown	IC50 4.89
Tissue factor	F3	unknown	IC50 4.39
Aromatase	CYP19A1	unknown	IC50 4.32
Nuclear receptor subfamily 4 group A member 2	NR4A2	unknown	Kd 4.30
Adenosine receptor A1	Adora1	unknown	IC50 4.19
Prostaglandin G/H synthase 2	PTGS2	unknown	IC50 4.03
NAD-dependent protein deacetylase sirtuin-6	SIRT6	unknown	EC50 4.00

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Hepatotoxicity	155.8
Hepatic necrosis	147.5
Hepatic encephalopathy	118.2
Hepatic cirrhosis	89.2
Drug-induced liver injury	80.3

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Linoleic acid is on its molecule page.

• Molecular formula: C₁₈H₃₂O₂
• Molecular weight: 280.45 g/mol
• CAS number: 60-33-3
• InChIKey: OYHQOLUKZRVURQ-HZJYTTRNSA-N
• PubChem CID: 5280450

CCCCC\C=C/C\C=C/CCCCCCCC(O)=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Linoleic acid work?

Its molecular targets in DrugCentral include FABP3, PPARA, AKR1C3 and FABP4.

What is the chemical formula of Linoleic acid?

Linoleic acid has the molecular formula C18H32O2 and a molecular weight of 280.45 g/mol.

Sources

• DrugCentral drug card 3323 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL267476 — compound record and bioactivity
• PubChem CID 5280450 — chemical identifiers
• DrugBank DB14104 — drug record
• FDA UNII 9KJL21T0QJ — substance identity
• UniProt P05413 (FABP3) — target protein
• UniProt Q07869 (PPARA) — target protein
• UniProt P42330 (AKR1C3) — target protein
• UniProt P15090 (FABP4) — target protein
• UniProt Q5NUL3 (FFAR4) — target protein
• UniProt O14842 (FFAR1) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.