About Peroxisome proliferator-activated receptor gamma
Peroxisome proliferator-activated receptor gamma (PPARG) is a protein
from Homo sapiens identified by UniProt accession
P37231, 505 residues long.
MolForge cross-references it against 0 known binders and
1,465 disease associations.
Target properties
| Protein name | Peroxisome proliferator-activated receptor gamma |
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| UniProt accession | P37231 |
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| Gene | PPARG |
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| Organism | Homo sapiens |
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| Length | 505 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (1465)
Diseases linked to this target (Open Targets).
- type 2 diabetes mellitus · score 0.84
- PPARG-related familial partial lipodystrophy · score 0.78
- diabetes mellitus · score 0.72
- high density lipoprotein cholesterol measurement · score 0.65
- ulcerative colitis · score 0.63
- non-alcoholic fatty liver disease · score 0.61
- obesity · score 0.60
- inherited obesity · score 0.57
- polycystic ovary syndrome · score 0.56
- metabolic syndrome · score 0.56
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P37231-F1 | alphafold | PREDICTED | 76.09 | — |
Amino-acid sequence (505 residues)
MGETLGDSPI DPESDSFTDT LSANISQEMT MVDTEMPFWP TNFGISSVDL SVMEDHSHSF DIKPFTTVDF SSISTPHYED IPFTRTDPVV ADYKYDLKLQ EYQSAIKVEP ASPPYYSEKT QLYNKPHEEP SNSLMAIECR VCGDKASGFH YGVHACEGCK GFFRRTIRLK LIYDRCDLNC RIHKKSRNKC QYCRFQKCLA VGMSHNAIRF GRMPQAEKEK LLAEISSDID QLNPESADLR ALAKHLYDSY IKSFPLTKAK ARAILTGKTT DKSPFVIYDM NSLMMGEDKI KFKHITPLQE QSKEVAIRIF QGCQFRSVEA VQEITEYAKS IPGFVNLDLN DQVTLLKYGV HEIIYTMLAS LMNKDGVLIS EGQGFMTREF LKSLRKPFGD FMEPKFEFAV KFNALELDDS DLAIFIAVII LSGDRPGLLN VKPIEDIQDN LLQALELQLK LNHPESSQLF AKLLQKMTDL RQIVTEHVQL LQVIKKTETD MSLHPLLQEI YKDLY
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