About Peroxisome proliferator-activated receptor alpha
Peroxisome proliferator-activated receptor alpha (PPARA) is a protein
from Homo sapiens identified by UniProt accession
Q07869, 468 residues long.
MolForge cross-references it against 0 known binders and
1,086 disease associations.
Target properties
| Protein name | Peroxisome proliferator-activated receptor alpha |
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| UniProt accession | Q07869 |
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| Gene | PPARA |
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| Organism | Homo sapiens |
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| Length | 468 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (1086)
Diseases linked to this target (Open Targets).
- type 2 diabetes mellitus · score 0.61
- Disorder of lipid metabolism · score 0.59
- Hypertriglyceridemia · score 0.58
- Hypercholesterolemia · score 0.58
- cardiovascular disease · score 0.57
- coronary artery disease · score 0.56
- Abnormal circulating lipid concentration · score 0.53
- diabetes mellitus · score 0.52
- diabetic retinopathy · score 0.52
- hypertension · score 0.46
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q07869-F1 | alphafold | PREDICTED | 80.19 | — |
Amino-acid sequence (468 residues)
MVDTESPLCP LSPLEAGDLE SPLSEEFLQE MGNIQEISQS IGEDSSGSFG FTEYQYLGSC PGSDGSVITD TLSPASSPSS VTYPVVPGSV DESPSGALNI ECRICGDKAS GYHYGVHACE GCKGFFRRTI RLKLVYDKCD RSCKIQKKNR NKCQYCRFHK CLSVGMSHNA IRFGRMPRSE KAKLKAEILT CEHDIEDSET ADLKSLAKRI YEAYLKNFNM NKVKARVILS GKASNNPPFV IHDMETLCMA EKTLVAKLVA NGIQNKEAEV RIFHCCQCTS VETVTELTEF AKAIPGFANL DLNDQVTLLK YGVYEAIFAM LSSVMNKDGM LVAYGNGFIT REFLKSLRKP FCDIMEPKFD FAMKFNALEL DDSDISLFVA AIICCGDRPG LLNVGHIEKM QEGIVHVLRL HLQSNHPDDI FLFPKLLQKM ADLRQLVTEH AQLVQIIKKT ESDAALHPLL QEIYRDMY
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