Clofibrate
CARDIOVASCULAR SYSTEM
Also known as: lipavil, lipavlon, lipomid, liprinal, miscleron, misclerone, p-chlorophenoxyisobutyric acid ethyl ester, ticlobran, xyduril
Data last refreshed: (DrugCentral release 2024-11-01)
Key facts
Clofibrate is an ofm drug catalogued in DrugCentral. It was first approved by the FDA in 1967. DrugCentral lists 2 molecular targets, including Fabp1 and PPARA. Recorded indications include Hyperlipidemia.
- Approval status: ofm (first approved 1967 by the FDA).
- Molecular targets: Fabp1 and PPARA (2 listed in DrugCentral).
- Indications: Hyperlipidemia.
- ATC code: C10AB01 (Fibrates).
- Molecular formula: C12H15ClO3; molecular weight 242.70 g/mol.
Indications & contraindications
Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).
Indications (1)
- Hyperlipidemia
Off-label uses (1)
- Partial Central Diabetes Insipidus
Mechanism & targets
Molecular targets (2)
| Target | Gene | Action | Activity |
|---|---|---|---|
| Fatty acid-binding protein, liver | Fabp1 | unknown | Kd 5.22 |
| Peroxisome proliferator-activated receptor alpha | PPARA | agonist | IC50 4.25 |
Regulatory approvals (1)
| Date | Agency | Marketed as | Applicant | Orphan |
|---|---|---|---|---|
| 1967-02-08 | FDA | — | — |
ATC classification
| ATC code | Therapeutic hierarchy |
|---|---|
C10AB01 | CARDIOVASCULAR SYSTEM › LIPID MODIFYING AGENTS › LIPID MODIFYING AGENTS, PLAIN › Fibrates |
Chemical structure
Full physicochemical, ADMET and 3D-structure analysis of Clofibrate is on its molecule page.
| Molecular formula | C12H15ClO3 |
|---|---|
| Molecular weight | 242.70 g/mol |
| CAS number | — |
| InChIKey | KNHUKKLJHYUCFP-UHFFFAOYSA-N |
| PubChem CID | 2796 |
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
What is Clofibrate used for?
DrugCentral lists the following indications for Clofibrate: Hyperlipidemia.
How does Clofibrate work?
Its molecular targets in DrugCentral include Fabp1 and PPARA (agonist).
When was Clofibrate first approved?
Clofibrate was first approved by the FDA in 1967.
What is the chemical formula of Clofibrate?
Clofibrate has the molecular formula C12H15ClO3 and a molecular weight of 242.70 g/mol.
Browse: all drugs starting with C · drug guides by category · protein targets A–Z.
Sources
- DrugCentral drug card 694 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
- ChEMBL CHEMBL565 — compound record and bioactivity
- PubChem CID 2796 — chemical identifiers
- DrugBank DB00636 — drug record
- FDA UNII HPN91K7FU3 — substance identity
- DailyMed: FDA labels for Clofibrate — current prescribing information (label search)
- UniProt Q07869 (PPARA) — target protein
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