Tissue factor (F3)

About Tissue factor

Tissue factor (F3) is a protein from Homo sapiens identified by UniProt accession P13726, 295 residues long. MolForge cross-references it against 0 known binders and 486 disease associations.

Target properties

Protein name	Tissue factor
UniProt accession	P13726
Gene	F3
Organism	Homo sapiens
Length	295 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (6)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (486)

Diseases linked to this target (Open Targets).

cervical cancer · score 0.47
neoplasm · score 0.39
tissue factor measurement · score 0.37
D dimer measurement · score 0.36
coagulation factor measurement · score 0.28
neutrophil count · score 0.26
squamous cell lung carcinoma · score 0.16
breast adenocarcinoma · score 0.13
creatinine measurement · score 0.13
head and neck squamous cell carcinoma · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P13726-F1	alphafold	PREDICTED	84.82	—

Amino-acid sequence (295 residues)

METPAWPRVP RPETAVARTL LLGWVFAQVA GASGTTNTVA AYNLTWKSTN FKTILEWEPK PVNQVYTVQI STKSGDWKSK CFYTTDTECD LTDEIVKDVK QTYLARVFSY PAGNVESTGS AGEPLYENSP EFTPYLETNL GQPTIQSFEQ VGTKVNVTVE DERTLVRRNN TFLSLRDVFG KDLIYTLYYW KSSSSGKKTA KTNTNEFLID VDKGENYCFS VQAVIPSRTV NRKSTDSPVE CMGQEKGEFR EIFYIIGAVV FVVIILVIIL AISLHKCRKA GVGQSWKENS PLNVS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards