Aldo-keto reductase family 1 member C3 (AKR1C3)

About Aldo-keto reductase family 1 member C3

Aldo-keto reductase family 1 member C3 (AKR1C3) is a protein from Homo sapiens identified by UniProt accession P42330, 323 residues long. MolForge cross-references it against 0 known binders and 273 disease associations.

Target properties

Protein name	Aldo-keto reductase family 1 member C3
UniProt accession	P42330
Gene	AKR1C3
Organism	Homo sapiens
Length	323 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (16)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (273)

Diseases linked to this target (Open Targets).

testosterone measurement · score 0.36
metabolite measurement · score 0.22
lung adenocarcinoma · score 0.22
cutaneous melanoma · score 0.18
heel bone mineral density · score 0.18
head and neck squamous cell carcinoma · score 0.17
breast adenocarcinoma · score 0.15
venous thromboembolism · score 0.13
prostate carcinoma · score 0.12
prostate cancer · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P42330-F1	alphafold	PREDICTED	96.56	—

Amino-acid sequence (323 residues)

MDSKHQCVKL NDGHFMPVLG FGTYAPPEVP RSKALEVTKL AIEAGFRHID SAHLYNNEEQ VGLAIRSKIA DGSVKREDIF YTSKLWSTFH RPELVRPALE NSLKKAQLDY VDLYLIHSPM SLKPGEELSP TDENGKVIFD IVDLCTTWEA MEKCKDAGLA KSIGVSNFNR RQLEMILNKP GLKYKPVCNQ VECHPYFNRS KLLDFCKSKD IVLVAYSALG SQRDKRWVDP NSPVLLEDPV LCALAKKHKR TPALIALRYQ LQRGVVVLAK SYNEQRIRQN VQVFEFQLTA EDMKAIDGLD RNLHYFNSDS FASHPNYPYS DEY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards