Dexibuprofen

MUSCULO-SKELETAL SYSTEM

Key facts

Dexibuprofen is a drug catalogued in DrugCentral. DrugCentral lists 6 molecular targets, including PTGS1, PTGS2 and PTGS1. Recorded indications include Dysmenorrhea, Fever, Headache disorder and Juvenile rheumatoid arthritis.

• Molecular targets: PTGS1, PTGS2, PTGS1 and PTGS2 (6 listed in DrugCentral).
• Indications: Dysmenorrhea, Fever, Headache disorder, Juvenile rheumatoid arthritis and Osteoarthritis and others.
• ATC code: M01AE14 (Propionic acid derivatives).
• Molecular formula: C13H18O2; molecular weight 206.28 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (7)

• Dysmenorrhea
• Fever
• Headache disorder
• Juvenile rheumatoid arthritis
• Osteoarthritis
• Pain
• Rheumatoid arthritis

Mechanism & targets

Molecular targets (6)

Target	Gene	Action	Activity
Prostaglandin G/H synthase 1	PTGS1	unknown	IC50 7.01
Prostaglandin G/H synthase 2	PTGS2	unknown	IC50 6.14
Prostaglandin G/H synthase 1	PTGS1	unknown	IC50 5.83
Prostaglandin G/H synthase 2	PTGS2	unknown	IC50 5.82
Aldo-keto reductase family 1 member C3	AKR1C3	unknown	IC50 4.49
Aldo-keto reductase family 1 member C2	AKR1C2	unknown	IC50 4.37

ATC classification

ATC code	Therapeutic hierarchy
M01AE14	MUSCULO-SKELETAL SYSTEM › ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS › ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS › Propionic acid derivatives

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Hemianopia	141.7
White blood cell count decreased	63.5
Skin fissures	60.9
Sopor	48.9
Ascites	43.0
Thrombocytopenia	40.4

Chemical structure

• Molecular formula: C₁₃H₁₈O₂
• Molecular weight: 206.28 g/mol
• CAS number: 51146-56-6
• InChIKey: HEFNNWSXXWATRW-JTQLQIEISA-N
• PubChem CID: 39912

CC(C)CC1=CC=C(C=C1)[C@H](C)C(O)=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Dexibuprofen used for?

DrugCentral lists the following indications for Dexibuprofen: Dysmenorrhea, Fever, Headache disorder, Juvenile rheumatoid arthritis, Osteoarthritis, Pain and Rheumatoid arthritis.

How does Dexibuprofen work?

Its molecular targets in DrugCentral include PTGS1, PTGS2, PTGS1 and PTGS2.

What is the chemical formula of Dexibuprofen?

Dexibuprofen has the molecular formula C13H18O2 and a molecular weight of 206.28 g/mol.

Sources

• DrugCentral drug card 3851 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL175 — compound record and bioactivity
• PubChem CID 39912 — chemical identifiers
• DrugBank DB09213 — drug record
• FDA UNII 671DKG7P5S — substance identity
• UniProt P23219 (PTGS1) — target protein
• UniProt P35354 (PTGS2) — target protein
• UniProt P42330 (AKR1C3) — target protein
• UniProt P52895 (AKR1C2) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.