Aldo-keto reductase family 1 member C2 (AKR1C2)

About Aldo-keto reductase family 1 member C2

Aldo-keto reductase family 1 member C2 (AKR1C2) is a protein from Homo sapiens identified by UniProt accession P52895, 323 residues long. MolForge cross-references it against 0 known binders and 113 disease associations.

Target properties

Protein name	Aldo-keto reductase family 1 member C2
UniProt accession	P52895
Gene	AKR1C2
Organism	Homo sapiens
Length	323 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (11)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (113)

Diseases linked to this target (Open Targets).

46,XY disorder of sex development due to isolated 17,20 lyase deficiency · score 0.66
46,XY complete gonadal dysgenesis · score 0.48
testosterone measurement · score 0.48
body height · score 0.31
neurofibrillary tangles measurement · score 0.29
neurodegenerative disease · score 0.24
lean body mass · score 0.23
BMI-adjusted waist-hip ratio · score 0.21
appendicular lean mass · score 0.20
waist-hip ratio · score 0.20

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P52895-F1	alphafold	PREDICTED	96.84	—

Amino-acid sequence (323 residues)

MDSKYQCVKL NDGHFMPVLG FGTYAPAEVP KSKALEAVKL AIEAGFHHID SAHVYNNEEQ VGLAIRSKIA DGSVKREDIF YTSKLWSNSH RPELVRPALE RSLKNLQLDY VDLYLIHFPV SVKPGEEVIP KDENGKILFD TVDLCATWEA MEKCKDAGLA KSIGVSNFNH RLLEMILNKP GLKYKPVCNQ VECHPYFNQR KLLDFCKSKD IVLVAYSALG SHREEPWVDP NSPVLLEDPV LCALAKKHKR TPALIALRYQ LQRGVVVLAK SYNEQRIRQN VQVFEFQLTS EEMKAIDGLN RNVRYLTLDI FAGPPNYPFS DEY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards