Fenoprofen

Nonsteroidal Anti-inflammatory Drug — MUSCULO-SKELETAL SYSTEM

Key facts

Fenoprofen is an ofp drug in the Nonsteroidal Anti-inflammatory Drug class catalogued in DrugCentral. It was first approved by the FDA in 1976. Its mechanism of action is classified as Cyclooxygenase Inhibitors. DrugCentral lists 5 molecular targets, including PTGS1, PTGS2 and PTGS2. Recorded indications include Osteoarthritis, Pain and Rheumatoid arthritis.

• Approval status: ofp (first approved 1976 by the FDA).
• Drug class: Nonsteroidal Anti-inflammatory Drug.
• Mechanism of action: Cyclooxygenase Inhibitors.
• Molecular targets: PTGS1, PTGS2, PTGS2 and SLC5A8 (5 listed in DrugCentral).
• Indications: Osteoarthritis, Pain and Rheumatoid arthritis.
• ATC code: M01AE04 (Propionic acid derivatives).
• Molecular formula: C15H14O3; molecular weight 242.27 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (3)

• Osteoarthritis
• Pain
• Rheumatoid arthritis

Off-label uses (3)

• Arthritis
• Gout
• Vascular headache

Contraindications (24)

• Acute papillary necrosis
• Alcoholism
• Anemia
• Blood coagulation disorder
• Body fluid retention
• Cardiovascular event risk
• Cerebrovascular accident
• Chronic heart failure
• Coronary artery bypass graft
• Disorder of cardiovascular system
• Drug-induced hepatitis
• Edema
• Gastrointestinal hemorrhage
• Gastrointestinal perforation
• Gastrointestinal ulcer
• Hearing disorder
• Hypertensive disorder
• Kidney disease
• Liver function tests abnormal
• Myocardial infarction
• Pregnancy, function
• Smokes tobacco daily
• Thrombosis
• Visual impairment

Mechanism & targets

• Mechanism of action (MoA): Cyclooxygenase Inhibitors
• Established pharmacologic class: Nonsteroidal Anti-inflammatory Drug

Molecular targets (5)

Target	Gene	Action	Activity
Prostaglandin G/H synthase 1	PTGS1	inhibitor	IC50 5.36
Prostaglandin G/H synthase 2	PTGS2	inhibitor	IC50 5.23
Prostaglandin G/H synthase 2	PTGS2	unknown	IC50 4.58
Sodium-coupled monocarboxylate transporter 1	SLC5A8	inhibitor	IC50 4.57
Cyclooxygenase	PTGS1|PTGS2	unknown	IC50 4.01

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1976-03-16	FDA	—	XSPIRE

ATC classification

ATC code	Therapeutic hierarchy
M01AE04	MUSCULO-SKELETAL SYSTEM › ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS › ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS › Propionic acid derivatives

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Fenoprofen is on its molecule page.

• Molecular formula: C₁₅H₁₄O₃
• Molecular weight: 242.27 g/mol
• CAS number: 29679-58-1
• InChIKey: RDJGLLICXDHJDY-UHFFFAOYSA-N
• PubChem CID: 3342

CC(C(O)=O)C1=CC=CC(OC2=CC=CC=C2)=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Fenoprofen used for?

DrugCentral lists the following indications for Fenoprofen: Osteoarthritis, Pain and Rheumatoid arthritis.

How does Fenoprofen work?

Fenoprofen is classified as Cyclooxygenase Inhibitors; its molecular targets in DrugCentral include PTGS1 (inhibitor), PTGS2 (inhibitor), PTGS2 and SLC5A8 (inhibitor).

When was Fenoprofen first approved?

Fenoprofen was first approved by the FDA in 1976.

What drug class does Fenoprofen belong to?

Fenoprofen is in the Nonsteroidal Anti-inflammatory Drug class.

What is the chemical formula of Fenoprofen?

Fenoprofen has the molecular formula C15H14O3 and a molecular weight of 242.27 g/mol.

Sources

• DrugCentral drug card 1154 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1297 — compound record and bioactivity
• PubChem CID 3342 — chemical identifiers
• DrugBank DB00573 — drug record
• FDA UNII RA33EAC7KY — substance identity
• DailyMed: FDA labels for Fenoprofen — current prescribing information (label search)
• UniProt P23219 (PTGS1) — target protein
• UniProt P35354 (PTGS2) — target protein
• UniProt Q8N695 (SLC5A8) — target protein

How this page is built: methodology · editorial policy & corrections.