About Sodium-coupled monocarboxylate transporter 1
Sodium-coupled monocarboxylate transporter 1 (SLC5A8) is a protein
from Homo sapiens identified by UniProt accession
Q8N695, 610 residues long.
MolForge cross-references it against 0 known binders and
101 disease associations.
Target properties
| Protein name | Sodium-coupled monocarboxylate transporter 1 |
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| UniProt accession | Q8N695 |
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| Gene | SLC5A8 |
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| Organism | Homo sapiens |
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| Length | 610 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (101)
Diseases linked to this target (Open Targets).
- BMI-adjusted waist-hip ratio · score 0.29
- BMI-adjusted waist circumference · score 0.29
- neurofibrillary tangles measurement · score 0.29
- cutaneous melanoma · score 0.13
- squamous cell lung carcinoma · score 0.11
- papillary thyroid carcinoma · score 0.08
- calf circumference measurement · score 0.08
- uridine-cytidineuria · score 0.05
- pentosuria · score 0.05
- axial length measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8N695-F1 | alphafold | PREDICTED | 85.72 | — |
Amino-acid sequence (610 residues)
MDTPRGIGTF VVWDYVVFAG MLVISAAIGI YYAFAGGGQQ TSKDFLMGGR RMTAVPVALS LTASFMSAVT VLGTPSEVYR FGAIFSIFAF TYFFVVVISA EVFLPVFYKL GITSTYEYLE LRFNKCVRLC GTVLFIVQTI LYTGIVIYAP ALALNQVTGF DLWGAVVATG VVCTFYCTLG GLKAVIWTDV FQVGIMVAGF ASVIIQAVVM QGGISTILND AYDGGRLNFW NFNPNPLQRH TFWTIIIGGT FTWTSIYGVN QSQVQRYISC KSRFQAKLSL YINLVGLWAI LTCSVFCGLA LYSRYHDCDP WTAKKVSAPD QLMPYLVLDI LQDYPGLPGL FVACAYSGTL STVSSSINAL AAVTVEDLIK PYFRSLSERS LSWISQGMSV VYGALCIGMA ALASLMGALL QAALSVFGMV GGPLMGLFAL GILVPFANSI GALVGLMAGF AISLWVGIGA QIYPPLPERT LPLHLDIQGC NSTYNETNLM TTTEMPFTTS VFQIYNVQRT PLMDNWYSLS YLYFSTVGTL VTLLVGILVS LSTGGRKQNL DPRYILTKED FLSNFDIFKK KKHVLSYKSH PVEDGGTDNP AFNHIELNSD QSGKSNGTRL
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