Benoxaprofen
MUSCULO-SKELETAL SYSTEM
Also known as: benoxaprofen ammonium, benoxaprofen monosodium, benoxaprofen sodium, dl-Benoxaprofen, oraflex
Data last refreshed: (DrugCentral release 2024-11-01)
Key facts
Benoxaprofen is a drug catalogued in DrugCentral. It was first approved by the FDA in 1982. DrugCentral lists 2 molecular targets, including Abcb11 and ALOX5. Recorded indications include Rheumatoid arthritis.
- Molecular targets: Abcb11 and ALOX5 (2 listed in DrugCentral).
- Indications: Rheumatoid arthritis.
- ATC code: M01AE06 (Propionic acid derivatives).
- Molecular formula: C16H12ClNO3; molecular weight 301.73 g/mol.
Indications & contraindications
Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).
Indications (1)
- Rheumatoid arthritis
Mechanism & targets
Molecular targets (2)
| Target | Gene | Action | Activity |
|---|---|---|---|
| Bile salt export pump | Abcb11 | unknown | IC50 4.00 |
| Arachidonate 5-lipoxygenase | ALOX5 | inhibitor | — |
Regulatory approvals (1)
| Date | Agency | Marketed as | Applicant | Orphan |
|---|---|---|---|---|
| 1982-04-19 | FDA | — | — |
ATC classification
| ATC code | Therapeutic hierarchy |
|---|---|
M01AE06 | MUSCULO-SKELETAL SYSTEM › ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS › ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS › Propionic acid derivatives |
Chemical structure
| Molecular formula | C16H12ClNO3 |
|---|---|
| Molecular weight | 301.73 g/mol |
| CAS number | 51234-28-7 |
| InChIKey | MITFXPHMIHQXPI-UHFFFAOYSA-N |
| PubChem CID | 39941 |
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
What is Benoxaprofen used for?
DrugCentral lists the following indications for Benoxaprofen: Rheumatoid arthritis.
How does Benoxaprofen work?
Its molecular targets in DrugCentral include Abcb11 and ALOX5 (inhibitor).
When was Benoxaprofen first approved?
Benoxaprofen was first approved by the FDA in 1982.
What is the chemical formula of Benoxaprofen?
Benoxaprofen has the molecular formula C16H12ClNO3 and a molecular weight of 301.73 g/mol.
Browse: all drugs starting with B · drug guides by category · protein targets A–Z.
Sources
- DrugCentral drug card 311 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
- ChEMBL CHEMBL340978 — compound record and bioactivity
- PubChem CID 39941 — chemical identifiers
- DrugBank DB04812 — drug record
- FDA UNII 17SZX404IM — substance identity
- DailyMed: FDA labels for Benoxaprofen — current prescribing information (label search)
- UniProt P09917 (ALOX5) — target protein
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