Carprofen

Drug profile

Key facts

Carprofen is an ofm drug catalogued in DrugCentral. It was first approved by the FDA in 1987. DrugCentral lists 5 molecular targets, including PTGS2, C5 and PTGS1.

• Approval status: ofm (first approved 1987 by the FDA).
• Molecular targets: PTGS2, C5, PTGS1 and PTGS1 (5 listed in DrugCentral).
• Molecular formula: C15H12ClNO2; molecular weight 273.72 g/mol.

Mechanism & targets

Molecular targets (5)

Target	Gene	Action	Activity
Prostaglandin G/H synthase 2	PTGS2	inhibitor	IC50 7.00
Complement C5	C5	unknown	Kd 6.24
Prostaglandin G/H synthase 1	PTGS1	unknown	IC50 4.89
Prostaglandin G/H synthase 1	PTGS1	unknown	IC50 4.88
Fatty-acid amide hydrolase 1	Faah	unknown	IC50 4.10

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1987-12-31	FDA	—	ROCHE

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Carprofen is on its molecule page.

• Molecular formula: C₁₅H₁₂ClNO₂
• Molecular weight: 273.72 g/mol
• CAS number: —
• InChIKey: PUXBGTOOZJQSKH-UHFFFAOYSA-N
• PubChem CID: 2581

CC(C(O)=O)C1=CC2=C(C=C1)C1=CC(Cl)=CC=C1N2

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Carprofen work?

Its molecular targets in DrugCentral include PTGS2 (inhibitor), C5, PTGS1 and PTGS1.

When was Carprofen first approved?

Carprofen was first approved by the FDA in 1987.

What is the chemical formula of Carprofen?

Carprofen has the molecular formula C15H12ClNO2 and a molecular weight of 273.72 g/mol.

Sources

• DrugCentral drug card 518 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1316 — compound record and bioactivity
• PubChem CID 2581 — chemical identifiers
• DrugBank DB00821 — drug record
• FDA UNII FFL0D546HO — substance identity
• DailyMed: FDA labels for Carprofen — current prescribing information (label search)
• UniProt P35354 (PTGS2) — target protein
• UniProt P01031 (C5) — target protein
• UniProt P23219 (PTGS1) — target protein

How this page is built: methodology · editorial policy & corrections.