Dexketoprofen

MUSCULO-SKELETAL SYSTEM

Key facts

Dexketoprofen is a drug catalogued in DrugCentral. DrugCentral lists 2 molecular targets, including PTGS1 and PTGS2.

• Molecular targets: PTGS1 and PTGS2 (2 listed in DrugCentral).
• ATC code: M01AE17 (Propionic acid derivatives).
• Molecular formula: C16H14O3; molecular weight 254.28 g/mol.

Mechanism & targets

Molecular targets (2)

Target	Gene	Action	Activity
Prostaglandin G/H synthase 1	PTGS1	inhibitor	IC50 8.72
Prostaglandin G/H synthase 2	PTGS2	inhibitor	IC50 7.57

ATC classification

ATC code	Therapeutic hierarchy
M01AE17	MUSCULO-SKELETAL SYSTEM › ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS › ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS › Propionic acid derivatives
M02AA27	MUSCULO-SKELETAL SYSTEM › TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN › TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN › Antiinflammatory preparations, non-steroids for topical use
N02AJ14	NERVOUS SYSTEM › ANALGESICS › OPIOIDS › Opioids in combination with non-opioid analgesics

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Acute kidney injury	132.5
Tubulointerstitial nephritis	115.0
Hyperaesthesia	105.5
Drug interaction	93.9
Polyneuropathy in malignant disease	93.9
Quality of life decreased	87.8
Pancreatic failure	76.2
Angioedema	75.8
Hyperbilirubinaemia	75.6
Allodynia	69.4
Hepatic cytolysis	68.1
Coagulopathy	63.5

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Dexketoprofen is on its molecule page.

• Molecular formula: C₁₆H₁₄O₃
• Molecular weight: 254.28 g/mol
• CAS number: 22161-81-5
• InChIKey: DKYWVDODHFEZIM-NSHDSACASA-N
• PubChem CID: 667550

C[C@H](C(O)=O)C1=CC=CC(=C1)C(=O)C1=CC=CC=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Dexketoprofen work?

Its molecular targets in DrugCentral include PTGS1 (inhibitor) and PTGS2 (inhibitor).

What is the chemical formula of Dexketoprofen?

Dexketoprofen has the molecular formula C16H14O3 and a molecular weight of 254.28 g/mol.

Sources

• DrugCentral drug card 833 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL75435 — compound record and bioactivity
• PubChem CID 667550 — chemical identifiers
• DrugBank DB09214 — drug record
• FDA UNII 6KD9E78X68 — substance identity
• UniProt P23219 (PTGS1) — target protein
• UniProt P35354 (PTGS2) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.