Aceclofenac

MUSCULO-SKELETAL SYSTEM

Key facts

Aceclofenac is a drug catalogued in DrugCentral. DrugCentral lists 4 molecular targets, including TTR, Akr1b1 and MAPK1. Recorded indications include Adhesive capsulitis of shoulder, Ankylosing spondylitis, Backache and Osteoarthritis.

• Molecular targets: TTR, Akr1b1, MAPK1 and PTGS2 (4 listed in DrugCentral).
• Indications: Adhesive capsulitis of shoulder, Ankylosing spondylitis, Backache, Osteoarthritis and Rheumatoid arthritis.
• ATC code: M01AB16 (Acetic acid derivatives and related substances).
• Molecular formula: C16H13Cl2NO4; molecular weight 354.18 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (5)

• Adhesive capsulitis of shoulder
• Ankylosing spondylitis
• Backache
• Osteoarthritis
• Rheumatoid arthritis

Mechanism & targets

Molecular targets (4)

Target	Gene	Action	Activity
Transthyretin	TTR	unknown	Kd 5.92
Aldose reductase	Akr1b1	unknown	IC50 5.89
Mitogen-activated protein kinase 1	MAPK1	unknown	IC50 5.23
Prostaglandin G/H synthase 2	PTGS2	inhibitor	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
—	FDA	—	—

ATC classification

ATC code	Therapeutic hierarchy
M01AB16	MUSCULO-SKELETAL SYSTEM › ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS › ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS › Acetic acid derivatives and related substances
M02AA25	MUSCULO-SKELETAL SYSTEM › TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN › TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN › Antiinflammatory preparations, non-steroids for topical use

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Amaurosis fugax	862.1
Ocular discomfort	777.3
Haemorrhagic stroke	764.4
Urinary tract disorder	705.8
Head discomfort	697.7
Blindness	578.3
Altered state of consciousness	575.8
Generalised oedema	559.0
Eye pain	542.3
Haematemesis	541.7
Presyncope	486.9
Diplopia	481.8

Chemical structure

• Molecular formula: C₁₆H₁₃Cl₂NO₄
• Molecular weight: 354.18 g/mol
• CAS number: 89796-99-6
• InChIKey: MNIPYSSQXLZQLJ-UHFFFAOYSA-N
• PubChem CID: 71771

OC(=O)COC(=O)CC1=C(NC2=C(Cl)C=CC=C2Cl)C=CC=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Aceclofenac used for?

DrugCentral lists the following indications for Aceclofenac: Adhesive capsulitis of shoulder, Ankylosing spondylitis, Backache, Osteoarthritis and Rheumatoid arthritis.

How does Aceclofenac work?

Its molecular targets in DrugCentral include TTR, Akr1b1, MAPK1 and PTGS2 (inhibitor).

What is the chemical formula of Aceclofenac?

Aceclofenac has the molecular formula C16H13Cl2NO4 and a molecular weight of 354.18 g/mol.

Sources

• DrugCentral drug card 43 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL93645 — compound record and bioactivity
• PubChem CID 71771 — chemical identifiers
• DrugBank DB06736 — drug record
• FDA UNII RPK779R03H — substance identity
• DailyMed: FDA labels for Aceclofenac — current prescribing information (label search)
• UniProt P02766 (TTR) — target protein
• UniProt P28482 (MAPK1) — target protein
• UniProt P35354 (PTGS2) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.