Acemetacin

MUSCULO-SKELETAL SYSTEM

Key facts

Acemetacin is a drug catalogued in DrugCentral. DrugCentral lists 3 molecular targets, including PTGS2, PTGS1 and GLO1. Recorded indications include Ankylosing spondylitis and Rheumatism.

• Molecular targets: PTGS2, PTGS1 and GLO1 (3 listed in DrugCentral).
• Indications: Ankylosing spondylitis and Rheumatism.
• ATC code: M01AB11 (Acetic acid derivatives and related substances).
• Molecular formula: C21H18ClNO6; molecular weight 415.83 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (2)

• Ankylosing spondylitis
• Rheumatism

Mechanism & targets

Molecular targets (3)

Target	Gene	Action	Activity
Prostaglandin G/H synthase 2	PTGS2	inhibitor	IC50 8.00
Prostaglandin G/H synthase 1	PTGS1	inhibitor	IC50 8.00
Lactoylglutathione lyase	GLO1	unknown	Ki 4.89

ATC classification

ATC code	Therapeutic hierarchy
M01AB11	MUSCULO-SKELETAL SYSTEM › ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS › ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS › Acetic acid derivatives and related substances

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Axial spondyloarthritis	257.4
Residual urine volume increased	120.5
Rotator cuff syndrome	101.7
Postoperative adhesion	97.1
Reactive gastropathy	93.4
Spinal osteoarthritis	91.6
Osteochondrosis	85.5
Hypertonic bladder	67.5
Intervertebral disc protrusion	67.2
Functional gastrointestinal disorder	60.7
Ovarian cyst	53.5
Meniscus injury	51.4

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Acemetacin is on its molecule page.

• Molecular formula: C₂₁H₁₈ClNO₆
• Molecular weight: 415.83 g/mol
• CAS number: 53164-05-9
• InChIKey: FSQKKOOTNAMONP-UHFFFAOYSA-N
• PubChem CID: 1981

COC1=CC2=C(C=C1)N(C(=O)C1=CC=C(Cl)C=C1)C(C)=C2CC(=O)OCC(O)=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Acemetacin used for?

DrugCentral lists the following indications for Acemetacin: Ankylosing spondylitis and Rheumatism.

How does Acemetacin work?

Its molecular targets in DrugCentral include PTGS2 (inhibitor), PTGS1 (inhibitor) and GLO1.

What is the chemical formula of Acemetacin?

Acemetacin has the molecular formula C21H18ClNO6 and a molecular weight of 415.83 g/mol.

Sources

• DrugCentral drug card 47 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL189171 — compound record and bioactivity
• PubChem CID 1981 — chemical identifiers
• DrugBank DB13783 — drug record
• FDA UNII 5V141XK28X — substance identity
• UniProt P35354 (PTGS2) — target protein
• UniProt P23219 (PTGS1) — target protein
• UniProt Q04760 (GLO1) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.