Lactoylglutathione lyase (GLO1)

About Lactoylglutathione lyase

Lactoylglutathione lyase (GLO1) is a protein from Homo sapiens identified by UniProt accession Q04760, 184 residues long. MolForge cross-references it against 0 known binders and 257 disease associations.

Target properties

Protein name	Lactoylglutathione lyase
UniProt accession	Q04760
Gene	GLO1
Organism	Homo sapiens
Length	184 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (6)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (257)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.45
autism · score 0.11
neoplasm · score 0.11
melanoma · score 0.10
schizophrenia · score 0.09
MODY · score 0.08
Ehlers-Danlos syndrome, musculocontractural type · score 0.07
glioblastoma multiforme · score 0.07
urinary bladder carcinoma · score 0.07
neuroendocrine neoplasm · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q04760-F1	alphafold	PREDICTED	95.37	—

Amino-acid sequence (184 residues)

MAEPQPPSGG LTDEAALSCC SDADPSTKDF LLQQTMLRVK DPKKSLDFYT RVLGMTLIQK CDFPIMKFSL YFLAYEDKND IPKEKDEKIA WALSRKATLE LTHNWGTEDD ETQSYHNGNS DPRGFGHIGI AVPDVYSACK RFEELGVKFV KKPDDGKMKG LAFIQDPDGY WIEILNPNKM ATLM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards