Sulfadimidine

ANTIINFECTIVES FOR SYSTEMIC USE

Key facts

Sulfadimidine is an ofm drug catalogued in DrugCentral. It was first approved by the FDA in 1949. DrugCentral lists 2 molecular targets, including folP and GLO1.

• Approval status: ofm (first approved 1949 by the FDA).
• Molecular targets: folP and GLO1 (2 listed in DrugCentral).
• ATC code: J01EB03 (Short-acting sulfonamides).
• Molecular formula: C12H14N4O2S; molecular weight 278.33 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Contraindications (8)

• Anemia due to enzyme deficiency
• Breastfeeding (mother)
• Disease of blood AND/OR blood-forming organ
• Disease of liver
• Kidney disease
• Megaloblastic anemia due to folate deficiency
• Porphyria
• Third trimester pregnancy

Mechanism & targets

Molecular targets (2)

Target	Gene	Action	Activity
Dihydropteroate synthase	folP	inhibitor	—
Lactoylglutathione lyase	GLO1	unknown	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1949-08-16	FDA	—	LEDERLE

ATC classification

ATC code	Therapeutic hierarchy
J01EB03	ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › SULFONAMIDES AND TRIMETHOPRIM › Short-acting sulfonamides
J01EE05	ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › SULFONAMIDES AND TRIMETHOPRIM › Combinations of sulfonamides and trimethoprim, incl. derivatives

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Sulfadimidine is on its molecule page.

• Molecular formula: C₁₂H₁₄N₄O₂S
• Molecular weight: 278.33 g/mol
• CAS number: 57-68-1
• InChIKey: ASWVTGNCAZCNNR-UHFFFAOYSA-N
• PubChem CID: 5327

CC1=CC(C)=NC(NS(=O)(=O)C2=CC=C(N)C=C2)=N1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Sulfadimidine work?

Its molecular targets in DrugCentral include folP (inhibitor) and GLO1.

When was Sulfadimidine first approved?

Sulfadimidine was first approved by the FDA in 1949.

What is the chemical formula of Sulfadimidine?

Sulfadimidine has the molecular formula C12H14N4O2S and a molecular weight of 278.33 g/mol.

Sources

• DrugCentral drug card 2502 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL446 — compound record and bioactivity
• PubChem CID 5327 — chemical identifiers
• DrugBank DB01582 — drug record
• FDA UNII 48U51W007F — substance identity
• DailyMed: FDA labels for Sulfadimidine — current prescribing information (label search)
• UniProt Q04760 (GLO1) — target protein

How this page is built: methodology · editorial policy & corrections.