Transthyretin (TTR)

About Transthyretin

Transthyretin (TTR) is a protein from Homo sapiens identified by UniProt accession P02766, 147 residues long. MolForge cross-references it against 0 known binders and 908 disease associations.

Target properties

Protein name	Transthyretin
UniProt accession	P02766
Gene	TTR
Organism	Homo sapiens
Length	147 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (16)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (908)

Diseases linked to this target (Open Targets).

familial amyloid neuropathy · score 0.88
Familial transthyretin-related amyloidosis · score 0.83
hereditary ATTR amyloidosis · score 0.73
cardiomyopathy · score 0.71
hyperthyroxinemia · score 0.71
carpal tunnel syndrome 1 · score 0.69
amyloidosis · score 0.66
carpal tunnel syndrome · score 0.63
cardiac amyloidosis · score 0.62
hereditary amyloidosis · score 0.58

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P02766-F1	alphafold	PREDICTED	87.99	—

Amino-acid sequence (147 residues)

MASHRLLLLC LAGLVFVSEA GPTGTGESKC PLMVKVLDAV RGSPAINVAV HVFRKAADDT WEPFASGKTS ESGELHGLTT EEEFVEGIYK VEIDTKSYWK ALGISPFHEH AEVVFTANDS GPRRYTIAAL LSPYSYSTTA VVTNPKE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards