Masoprocol

ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS

Key facts

Masoprocol is an ofm drug catalogued in DrugCentral. It was first approved by the FDA in 1992. DrugCentral lists 25 molecular targets, including Alox5, CYP19A1 and ALOX5. Recorded indications include Actinic keratosis.

• Approval status: ofm (first approved 1992 by the FDA).
• Molecular targets: Alox5, CYP19A1, ALOX5 and LTB4R (25 listed in DrugCentral).
• Indications: Actinic keratosis.
• ATC code: L01XX10 (Other antineoplastic agents).
• Molecular formula: C18H22O4; molecular weight 302.37 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Actinic keratosis

Mechanism & targets

Molecular targets (25)

Target	Gene	Action	Activity
Arachidonate 5-lipoxygenase	Alox5	unknown	IC50 8.00
Aromatase	CYP19A1	unknown	IC50 7.96
Arachidonate 5-lipoxygenase	ALOX5	unknown	IC50 7.60
Leukotriene B4 receptor 1	LTB4R	unknown	IC50 7.07
Arachidonate 15-lipoxygenase	ALOX15	unknown	IC50 6.96
Arachidonate 12-lipoxygenase, 12S-type	ALOX12	unknown	IC50 6.96
Arachidonate 15-lipoxygenase	ALOX15	unknown	IC50 6.96
Seed linoleate 13S-lipoxygenase-1	LOX1.1	unknown	IC50 6.74
Alpha-synuclein	SNCA	unknown	IC50 6.68
Estradiol 17-beta-dehydrogenase 2	HSD17B2	unknown	IC50 6.42
Arachidonate 5-lipoxygenase	Alox5	unknown	IC50 6.40
5-lipoxygenase	—	unknown	IC50 6.40
Insulin-like growth factor 1 receptor	IGF1R	unknown	IC50 6.05
Transient receptor potential cation channel subfamily A member 1	TRPA1	unknown	EC50 5.31
Estradiol 17-beta-dehydrogenase 1	HSD17B1	unknown	IC50 5.26
Transthyretin	TTR	unknown	EC50 5.14
Zinc finger protein mex-5	mex-5	unknown	EC50 5.06
Arachidonate 15-lipoxygenase, type II	ALOX15B	unknown	IC50 4.96
Cyclooxygenase	PTGS1|PTGS2	unknown	IC50 4.85
Estrogen receptor	ESR1	unknown	IC50 4.65

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1992-09-04	FDA	—	—

ATC classification

ATC code	Therapeutic hierarchy
L01XX10	ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS › ANTINEOPLASTIC AGENTS › OTHER ANTINEOPLASTIC AGENTS › Other antineoplastic agents

Chemical structure

• Molecular formula: C₁₈H₂₂O₄
• Molecular weight: 302.37 g/mol
• CAS number: 27686-84-6
• InChIKey: HCZKYJDFEPMADG-TXEJJXNPSA-N
• PubChem CID: 71398

C[C@@H](CC1=CC(O)=C(O)C=C1)[C@H](C)CC1=CC(O)=C(O)C=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Masoprocol used for?

DrugCentral lists the following indications for Masoprocol: Actinic keratosis.

How does Masoprocol work?

Its molecular targets in DrugCentral include Alox5, CYP19A1, ALOX5 and LTB4R.

When was Masoprocol first approved?

Masoprocol was first approved by the FDA in 1992.

What is the chemical formula of Masoprocol?

Masoprocol has the molecular formula C18H22O4 and a molecular weight of 302.37 g/mol.

Sources

• DrugCentral drug card 1637 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL313972 — compound record and bioactivity
• PubChem CID 71398 — chemical identifiers
• DrugBank DB00179 — drug record
• FDA UNII 7BO8G1BYQU — substance identity
• DailyMed: FDA labels for Masoprocol — current prescribing information (label search)
• UniProt P11511 (CYP19A1) — target protein
• UniProt P09917 (ALOX5) — target protein
• UniProt Q15722 (LTB4R) — target protein
• UniProt P18054 (ALOX12) — target protein
• UniProt P16050 (ALOX15) — target protein
• UniProt P37840 (SNCA) — target protein

How this page is built: methodology · editorial policy & corrections.