About 17-beta-hydroxysteroid dehydrogenase type 2
17-beta-hydroxysteroid dehydrogenase type 2 (HSD17B2) is a protein
from Homo sapiens identified by UniProt accession
P37059, 387 residues long.
MolForge cross-references it against 0 known binders and
94 disease associations.
Target properties
| Protein name | 17-beta-hydroxysteroid dehydrogenase type 2 |
|---|
| UniProt accession | P37059 |
|---|
| Gene | HSD17B2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 387 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (94)
Diseases linked to this target (Open Targets).
- ovarian cancer · score 0.19
- vitamin D measurement · score 0.12
- head and neck squamous cell carcinoma · score 0.11
- mean platelet volume · score 0.09
- neoplasm · score 0.08
- cancer · score 0.08
- non-small cell lung carcinoma · score 0.07
- Barrett's esophagus · score 0.07
- coronary artery disease · score 0.06
- laryngotracheoesophageal cleft · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P37059-F1 | alphafold | PREDICTED | 87.73 | — |
Amino-acid sequence (387 residues)
MSTFFSDTAW ICLAVPTVLC GTVFCKYKKS SGQLWSWMVC LAGLCAVCLL ILSPFWGLIL FSVSCFLMYT YLSGQELLPV DQKAVLVTGG DCGLGHALCK YLDELGFTVF AGVLNENGPG AEELRRTCSP RLSVLQMDIT KPVQIKDAYS KVAAMLQDRG LWAVINNAGV LGFPTDGELL LMTDYKQCMA VNFFGTVEVT KTFLPLLRKS KGRLVNVSSM GGGAPMERLA SYGSSKAAVT MFSSVMRLEL SKWGIKVASI QPGGFLTNIA GTSDKWEKLE KDILDHLPAE VQEDYGQDYI LAQRNFLLLI NSLASKDFSP VLRDIQHAIL AKSPFAYYTP GKGAYLWICL AHYLPIGIYD YFAKRHFGQD KPMPRALRMP NYKKKAT
Explore 17-beta-hydroxysteroid dehydrogenase type 2 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets