About 17-beta-hydroxysteroid dehydrogenase type 1
17-beta-hydroxysteroid dehydrogenase type 1 (HSD17B1) is a protein
from Homo sapiens identified by UniProt accession
P14061, 328 residues long.
MolForge cross-references it against 0 known binders and
214 disease associations.
Target properties
| Protein name | 17-beta-hydroxysteroid dehydrogenase type 1 |
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| UniProt accession | P14061 |
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| Gene | HSD17B1 |
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| Organism | Homo sapiens |
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| Length | 328 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (214)
Diseases linked to this target (Open Targets).
- triglyceride measurement · score 0.23
- squamous cell lung carcinoma · score 0.16
- serum gamma-glutamyl transferase measurement · score 0.13
- lymphocyte count · score 0.12
- type 2 diabetes mellitus · score 0.09
- serum albumin measurement · score 0.09
- bladder transitional cell carcinoma · score 0.08
- waist-hip ratio · score 0.07
- 46,XX gonadal dysgenesis · score 0.07
- primary ovarian insufficiency · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P14061-F1 | alphafold | PREDICTED | 89.84 | — |
Amino-acid sequence (328 residues)
MARTVVLITG CSSGIGLHLA VRLASDPSQS FKVYATLRDL KTQGRLWEAA RALACPPGSL ETLQLDVRDS KSVAAARERV TEGRVDVLVC NAGLGLLGPL EALGEDAVAS VLDVNVVGTV RMLQAFLPDM KRRGSGRVLV TGSVGGLMGL PFNDVYCASK FALEGLCESL AVLLLPFGVH LSLIECGPVH TAFMEKVLGS PEEVLDRTDI HTFHRFYQYL AHSKQVFREA AQNPEEVAEV FLTALRAPKP TLRYFTTERF LPLLRMRLDD PSGSNYVTAM HREVFGDVPA KAEAGAEAGG GAGPGAEDEA GRGAVGDPEL GDPPAAPQ
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