About Polyunsaturated fatty acid lipoxygenase ALOX15B
Polyunsaturated fatty acid lipoxygenase ALOX15B (ALOX15B) is a protein
from Homo sapiens identified by UniProt accession
O15296, 676 residues long.
MolForge cross-references it against 0 known binders and
150 disease associations.
Target properties
| Protein name | Polyunsaturated fatty acid lipoxygenase ALOX15B |
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| UniProt accession | O15296 |
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| Gene | ALOX15B |
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| Organism | Homo sapiens |
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| Length | 676 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (150)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.23
- sex hormone-binding globulin measurement · score 0.16
- cutaneous melanoma · score 0.12
- head and neck squamous cell carcinoma · score 0.11
- refractive error measurement · score 0.10
- neoplasm · score 0.05
- neutrophil count · score 0.05
- pulmonary blastoma · score 0.04
- immunodeficiency 51 · score 0.04
- idiopathic bronchiectasis · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15296-F1 | alphafold | PREDICTED | 95.16 | — |
Amino-acid sequence (676 residues)
MAEFRVRVST GEAFGAGTWD KVSVSIVGTR GESPPLPLDN LGKEFTAGAE EDFQVTLPED VGRVLLLRVH KAPPVLPLLG PLAPDAWFCR WFQLTPPRGG HLLFPCYQWL EGAGTLVLQE GTAKVSWADH HPVLQQQRQE ELQARQEMYQ WKAYNPGWPH CLDEKTVEDL ELNIKYSTAK NANFYLQAGS AFAEMKIKGL LDRKGLWRSL NEMKRIFNFR RTPAAEHAFE HWQEDAFFAS QFLNGLNPVL IRRCHYLPKN FPVTDAMVAS VLGPGTSLQA ELEKGSLFLV DHGILSGIQT NVINGKPQFS AAPMTLLYQS PGCGPLLPLA IQLSQTPGPN SPIFLPTDDK WDWLLAKTWV RNAEFSFHEA LTHLLHSHLL PEVFTLATLR QLPHCHPLFK LLIPHTRYTL HINTLARELL IVPGQVVDRS TGIGIEGFSE LIQRNMKQLN YSLLCLPEDI RTRGVEDIPG YYYRDDGMQI WGAVERFVSE IIGIYYPSDE SVQDDRELQA WVREIFSKGF LNQESSGIPS SLETREALVQ YVTMVIFTCS AKHAAVSAGQ FDSCAWMPNL PPSMQLPPPT SKGLATCEGF IATLPPVNAT CDVILALWLL SKEPGDQRPL GTYPDEHFTE EAPRRSIATF QSRLAQISRG IQERNQGLVL PYTYLDPPLI ENSVSI
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