Chloroxine

Drug profile

Key facts

Chloroxine is an ofm drug catalogued in DrugCentral. It was first approved by the FDA in 1976. DrugCentral lists 10 molecular targets, including ALOX12, MMP14 and ALOX15. Recorded indications include Pityriasis simplex and Seborrheic dermatitis.

• Approval status: ofm (first approved 1976 by the FDA).
• Molecular targets: ALOX12, MMP14, ALOX15 and ALOX5 (10 listed in DrugCentral).
• Indications: Pityriasis simplex and Seborrheic dermatitis.
• Molecular formula: C9H5Cl2NO; molecular weight 214.05 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (2)

• Pityriasis simplex
• Seborrheic dermatitis

Contraindications (1)

• Denuded skin

Mechanism & targets

Molecular targets (10)

Target	Gene	Action	Activity
Arachidonate 12-lipoxygenase, 12S-type	ALOX12	unknown	IC50 5.72
Matrix metalloproteinase-14	MMP14	unknown	Kd 5.62
Arachidonate 15-lipoxygenase	ALOX15	unknown	IC50 5.62
Arachidonate 5-lipoxygenase	ALOX5	unknown	IC50 5.44
Replicase polyprotein 1ab	REP	unknown	Kd 5.34
Beta-lactamase NDM-1	blaNDM-1	unknown	IC50 5.31
Botulinum neurotoxin type A	botA	unknown	IC50 4.94
Matrix metalloproteinase-9	MMP9	unknown	IC50 4.80
Collagenase 3	MMP13	unknown	IC50 4.71
Arachidonate 15-lipoxygenase, type II	ALOX15B	unknown	IC50 4.55

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1976-10-19	FDA	—	—

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Chloroxine is on its molecule page.

• Molecular formula: C₉H₅Cl₂NO
• Molecular weight: 214.05 g/mol
• CAS number: 773-76-2
• InChIKey: WDFKMLRRRCGAKS-UHFFFAOYSA-N
• PubChem CID: 2722

OC1=C2N=CC=CC2=C(Cl)C=C1Cl

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Chloroxine used for?

DrugCentral lists the following indications for Chloroxine: Pityriasis simplex and Seborrheic dermatitis.

How does Chloroxine work?

Its molecular targets in DrugCentral include ALOX12, MMP14, ALOX15 and ALOX5.

When was Chloroxine first approved?

Chloroxine was first approved by the FDA in 1976.

What is the chemical formula of Chloroxine?

Chloroxine has the molecular formula C9H5Cl2NO and a molecular weight of 214.05 g/mol.

Sources

• DrugCentral drug card 611 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1200596 — compound record and bioactivity
• PubChem CID 2722 — chemical identifiers
• DrugBank DB01243 — drug record
• FDA UNII 2I8BD50I8B — substance identity
• DailyMed: FDA labels for Chloroxine — current prescribing information (label search)
• UniProt P18054 (ALOX12) — target protein
• UniProt P50281 (MMP14) — target protein
• UniProt P16050 (ALOX15) — target protein
• UniProt P09917 (ALOX5) — target protein
• UniProt P14780 (MMP9) — target protein
• UniProt P45452 (MMP13) — target protein

How this page is built: methodology · editorial policy & corrections.