Collagenase 3 (MMP13)

About Collagenase 3

Collagenase 3 (MMP13) is a protein from Homo sapiens identified by UniProt accession P45452, 471 residues long. MolForge cross-references it against 0 known binders and 696 disease associations.

Target properties

Protein name	Collagenase 3
UniProt accession	P45452
Gene	MMP13
Organism	Homo sapiens
Length	471 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (4)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (696)

Diseases linked to this target (Open Targets).

spondyloepimetaphyseal dysplasia, Missouri type · score 0.79
metaphyseal chondrodysplasia, Spahr type · score 0.68
acne · score 0.61
rosacea · score 0.59
periodontitis · score 0.59
Helicobacter pylori infectious disease · score 0.59
infection · score 0.58
COVID-19 · score 0.58
Lyme disease · score 0.57
Borrelia infectious disease · score 0.56

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P45452-F1	alphafold	PREDICTED	88.60	—

Amino-acid sequence (471 residues)

MHPGVLAAFL FLSWTHCRAL PLPSGGDEDD LSEEDLQFAE RYLRSYYHPT NLAGILKENA ASSMTERLRE MQSFFGLEVT GKLDDNTLDV MKKPRCGVPD VGEYNVFPRT LKWSKMNLTY RIVNYTPDMT HSEVEKAFKK AFKVWSDVTP LNFTRLHDGI ADIMISFGIK EHGDFYPFDG PSGLLAHAFP PGPNYGGDAH FDDDETWTSS SKGYNLFLVA AHEFGHSLGL DHSKDPGALM FPIYTYTGKS HFMLPDDDVQ GIQSLYGPGD EDPNPKHPKT PDKCDPSLSL DAITSLRGET MIFKDRFFWR LHPQQVDAEL FLTKSFWPEL PNRIDAAYEH PSHDLIFIFR GRKFWALNGY DILEGYPKKI SELGLPKEVK KISAAVHFED TGKTLLFSGN QVWRYDDTNH IMDKDYPRLI EEDFPGIGDK VDAVYEKNGY IYFFNGPIQF EYSIWSNRIV RVMPANSILW C

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards