About Polyunsaturated fatty acid lipoxygenase ALOX12
Polyunsaturated fatty acid lipoxygenase ALOX12 (ALOX12) is a protein
from Homo sapiens identified by UniProt accession
P18054, 663 residues long.
MolForge cross-references it against 0 known binders and
215 disease associations.
Target properties
| Protein name | Polyunsaturated fatty acid lipoxygenase ALOX12 |
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| UniProt accession | P18054 |
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| Gene | ALOX12 |
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| Organism | Homo sapiens |
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| Length | 663 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (215)
Diseases linked to this target (Open Targets).
- esophageal squamous cell carcinoma · score 0.40
- colorectal neoplasm · score 0.37
- colorectal adenocarcinoma · score 0.37
- esophageal cancer · score 0.37
- rheumatic disease · score 0.37
- colorectal cancer · score 0.37
- neurodegenerative disease · score 0.33
- mean platelet volume · score 0.25
- lymphocyte count · score 0.18
- neutrophil percentage of leukocytes · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P18054-F1 | alphafold | PREDICTED | 95.41 | — |
Amino-acid sequence (663 residues)
MGRYRIRVAT GAWLFSGSYN RVQLWLVGTR GEAELELQLR PARGEEEEFD HDVAEDLGLL QFVRLRKHHW LVDDAWFCDR ITVQGPGACA EVAFPCYRWV QGEDILSLPE GTARLPGDNA LDMFQKHREK ELKDRQQIYC WATWKEGLPL TIAADRKDDL PPNMRFHEEK RLDFEWTLKA GALEMALKRV YTLLSSWNCL EDFDQIFWGQ KSALAEKVRQ CWQDDELFSY QFLNGANPML LRRSTSLPSR LVLPSGMEEL QAQLEKELQN GSLFEADFIL LDGIPANVIR GEKQYLAAPL VMLKMEPNGK LQPMVIQIQP PNPSSPTPTL FLPSDPPLAW LLAKSWVRNS DFQLHEIQYH LLNTHLVAEV IAVATMRCLP GLHPIFKFLI PHIRYTMEIN TRARTQLISD GGIFDKAVST GGGGHVQLLR RAAAQLTYCS LCPPDDLADR GLLGLPGALY AHDALRLWEI IARYVEGIVH LFYQRDDIVK GDPELQAWCR EITEVGLCQA QDRGFPVSFQ SQSQLCHFLT MCVFTCTAQH AAINQGQLDW YAWVPNAPCT MRMPPPTTKE DVTMATVMGS LPDVRQACLQ MAISWHLSRR QPDMVPLGHH KEKYFSGPKP KAVLNQFRTD LEKLEKEITA RNEQLDWPYE YLKPSCIENS VTI
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