About Matrix metalloproteinase-14
Matrix metalloproteinase-14 (MMP14) is a protein
from Homo sapiens identified by UniProt accession
P50281, 582 residues long.
MolForge cross-references it against 0 known binders and
702 disease associations.
Target properties
| Protein name | Matrix metalloproteinase-14 |
|---|
| UniProt accession | P50281 |
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| Gene | MMP14 |
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| Organism | Homo sapiens |
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| Length | 582 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (4)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (702)
Diseases linked to this target (Open Targets).
- Torg-Winchester syndrome · score 0.58
- Nodulosis-arthropathy-osteolysis syndrome · score 0.46
- heel bone mineral density · score 0.40
- body height · score 0.38
- multicentric osteolysis-nodulosis-arthropathy spectrum · score 0.37
- FEV/FVC ratio · score 0.34
- frozen shoulder · score 0.33
- bone quantitative ultrasound measurement · score 0.33
- diastolic blood pressure · score 0.29
- Dupuytren Contracture · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P50281-F1 | alphafold | PREDICTED | 80.78 | — |
Amino-acid sequence (582 residues)
MSPAPRPPRC LLLPLLTLGT ALASLGSAQS SSFSPEAWLQ QYGYLPPGDL RTHTQRSPQS LSAAIAAMQK FYGLQVTGKA DADTMKAMRR PRCGVPDKFG AEIKANVRRK RYAIQGLKWQ HNEITFCIQN YTPKVGEYAT YEAIRKAFRV WESATPLRFR EVPYAYIREG HEKQADIMIF FAEGFHGDST PFDGEGGFLA HAYFPGPNIG GDTHFDSAEP WTVRNEDLNG NDIFLVAVHE LGHALGLEHS SDPSAIMAPF YQWMDTENFV LPDDDRRGIQ QLYGGESGFP TKMPPQPRTT SRPSVPDKPK NPTYGPNICD GNFDTVAMLR GEMFVFKERW FWRVRNNQVM DGYPMPIGQF WRGLPASINT AYERKDGKFV FFKGDKHWVF DEASLEPGYP KHIKELGRGL PTDKIDAALF WMPNGKTYFF RGNKYYRFNE ELRAVDSEYP KNIKVWEGIP ESPRGSFMGS DEVFTYFYKG NKYWKFNNQK LKVEPGYPKS ALRDWMGCPS GGRPDEGTEE ETEVIIIEVD EEGGGAVSAA AVVLPVLLLL LVLAVGLAVF FFRRHGTPRR LLYCQRSLLD KV
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