Clioquinol

Standardized Chemical Allergen — DERMATOLOGICALS

Key facts

Clioquinol is an ofm drug in the Standardized Chemical Allergen class catalogued in DrugCentral. DrugCentral lists 9 molecular targets, including MMP14, Ca15 and blaNDM-1. Recorded indications include Tinea corporis, Tinea cruris and Tinea pedis.

• Approval status: ofm.
• Drug class: Standardized Chemical Allergen.
• Molecular targets: MMP14, Ca15, blaNDM-1 and Comt (9 listed in DrugCentral).
• Indications: Tinea corporis, Tinea cruris and Tinea pedis.
• ATC code: D08AH30 (Quinoline derivatives).
• Molecular formula: C9H5ClINO; molecular weight 305.50 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (3)

• Tinea corporis
• Tinea cruris
• Tinea pedis

Contraindications (5)

• Adrenal cortical hypofunction
• Atrophoderma
• Open wound
• Peripheral vascular disease
• Telangiectasia disorder

Mechanism & targets

• Established pharmacologic class: Standardized Chemical Allergen

Molecular targets (9)

Target	Gene	Action	Activity
Matrix metalloproteinase-14	MMP14	unknown	Kd 5.92
Carbonic anhydrase 15	Ca15	unknown	Ki 5.63
Beta-lactamase NDM-1	blaNDM-1	unknown	IC50 5.52
Catechol O-methyltransferase	Comt	unknown	IC50 5.32
Spike glycoprotein	S	unknown	IC50 5.25
Botulinum neurotoxin type A	botA	unknown	IC50 4.69
Methionine aminopeptidase 2	METAP2	unknown	IC50 4.09
Methionine aminopeptidase 1	METAP1	unknown	IC50 4.07
Amyloid beta A4 protein	APP	unknown	IC50 4.00

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
—	FDA	—	—

ATC classification

ATC code	Therapeutic hierarchy
D08AH30	DERMATOLOGICALS › ANTISEPTICS AND DISINFECTANTS › ANTISEPTICS AND DISINFECTANTS › Quinoline derivatives
D09AA10	DERMATOLOGICALS › MEDICATED DRESSINGS › MEDICATED DRESSINGS › Medicated dressings with antiinfectives
G01AC02	GENITO URINARY SYSTEM AND SEX HORMONES › GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS › ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS › Quinoline derivatives
P01AA02	ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS › ANTIPROTOZOALS › AGENTS AGAINST AMOEBIASIS AND OTHER PROTOZOAL DISEASES › Hydroxyquinoline derivatives
P01AA52	ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS › ANTIPROTOZOALS › AGENTS AGAINST AMOEBIASIS AND OTHER PROTOZOAL DISEASES › Hydroxyquinoline derivatives
S02AA05	SENSORY ORGANS › OTOLOGICALS › ANTIINFECTIVES › Antiinfectives

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Porphyria acute	187.5
Dislocation of vertebra	153.2
Frequent bowel movements	133.1
C-reactive protein abnormal	126.3
Peripheral venous disease	120.6
Oedema	113.3
X-ray abnormal	109.8
Injury	101.2
Prescribed overdose	96.4
Lip dry	95.8
Colitis ulcerative	95.8
Joint range of motion decreased	95.5

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Clioquinol is on its molecule page.

• Molecular formula: C₉H₅ClINO
• Molecular weight: 305.50 g/mol
• CAS number: 130-26-7
• InChIKey: QCDFBFJGMNKBDO-UHFFFAOYSA-N
• PubChem CID: 2788

OC1=C2N=CC=CC2=C(Cl)C=C1I

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Clioquinol used for?

DrugCentral lists the following indications for Clioquinol: Tinea corporis, Tinea cruris and Tinea pedis.

How does Clioquinol work?

Its molecular targets in DrugCentral include MMP14, Ca15, blaNDM-1 and Comt.

What drug class does Clioquinol belong to?

Clioquinol is in the Standardized Chemical Allergen class.

What is the chemical formula of Clioquinol?

Clioquinol has the molecular formula C9H5ClINO and a molecular weight of 305.50 g/mol.

Sources

• DrugCentral drug card 681 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL497 — compound record and bioactivity
• PubChem CID 2788 — chemical identifiers
• DrugBank DB04815 — drug record
• FDA UNII 7BHQ856EJ5 — substance identity
• DailyMed: FDA labels for Clioquinol — current prescribing information (label search)
• UniProt P50281 (MMP14) — target protein
• UniProt P50579 (METAP2) — target protein
• UniProt P53582 (METAP1) — target protein
• UniProt P05067 (APP) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.