Acetic acid

GENITO URINARY SYSTEM AND SEX HORMONES

Key facts

Acetic acid is a drug catalogued in DrugCentral. It was first approved by the FDA in 1960. DrugCentral lists 4 molecular targets, including LCK, FYN and FFAR3. Recorded indications include Otitis externa.

• Molecular targets: LCK, FYN, FFAR3 and FFAR2 (4 listed in DrugCentral).
• Indications: Otitis externa.
• ATC code: G01AD02 (Organic acids).
• Molecular formula: C2H4O2; molecular weight 60.05 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Otitis externa

Off-label uses (4)

• Impacted cerumen
• Otalgia
• Otitis Externa Eczema
• Otitis Externa Seborrhea

Contraindications (9)

• Fungal ear infection
• Herpes simplex
• Herpes zoster auricularis
• Infective otitis media
• Perforation of tympanic membrane
• Porphyria
• Sensation Disturbance of Genitals
• Tuberculosis of ear
• Viral ear infection

Mechanism & targets

Molecular targets (4)

Target	Gene	Action	Activity
Tyrosine-protein kinase Lck	LCK	unknown	Kd 6.19
Tyrosine-protein kinase Fyn	FYN	unknown	Kd 6.05
Free fatty acid receptor 3	FFAR3	unknown	EC50 4.92
Free fatty acid receptor 2	FFAR2	agonist	EC50 4.60

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1960-05-17	FDA	—	HI TECH PHARMA

ATC classification

ATC code	Therapeutic hierarchy
G01AD02	GENITO URINARY SYSTEM AND SEX HORMONES › GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS › ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS › Organic acids
S02AA10	SENSORY ORGANS › OTOLOGICALS › ANTIINFECTIVES › Antiinfectives

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Joint dislocation	242.7
Seronegative arthritis	181.6
Joint stiffness	176.0
Prescribed underdose	161.8
Wound infection	125.4
Psoriasis	122.1
Lupus vulgaris	121.0
Walking aid user	120.2
Retinitis	120.1
Osteoporosis	120.1
Joint range of motion decreased	115.9
Visual impairment	111.2

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Acetic acid is on its molecule page.

• Molecular formula: C₂H₄O₂
• Molecular weight: 60.05 g/mol
• CAS number: 64-19-7
• InChIKey: QTBSBXVTEAMEQO-UHFFFAOYSA-N
• PubChem CID: 176

CC(O)=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Acetic acid used for?

DrugCentral lists the following indications for Acetic acid: Otitis externa.

How does Acetic acid work?

Its molecular targets in DrugCentral include LCK, FYN, FFAR3 and FFAR2 (agonist).

When was Acetic acid first approved?

Acetic acid was first approved by the FDA in 1960.

What is the chemical formula of Acetic acid?

Acetic acid has the molecular formula C2H4O2 and a molecular weight of 60.05 g/mol.

Sources

• DrugCentral drug card 4211 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL539 — compound record and bioactivity
• PubChem CID 176 — chemical identifiers
• DrugBank DB03166 — drug record
• FDA UNII Q40Q9N063P — substance identity
• DailyMed: FDA labels for Acetic acid — current prescribing information (label search)
• UniProt P06239 (LCK) — target protein
• UniProt P06241 (FYN) — target protein
• UniProt O14843 (FFAR3) — target protein
• UniProt O15552 (FFAR2) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.